Basic Information

Symbol
APOC1
RNA class
mRNA
Alias
Apolipoprotein C1 Apo-CI ApoC-I Apolipoprotein C-I Apo-CIB ApoC-IB APOC1B
Location (GRCh38)
19:44913133-44920054
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001645.5
Sequence length
514.0 nt
GC content
0.5778

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-202.10 kcal/mol
Thermodynamic ensemble
Free energy: -209.20 kcal/mol
Frequency: 0.0000
Diversity: 66.78
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((.(((..((((((((((..(((((.(((.(..................).))))))))..))))).....(((((((((......).)))))))).....((..((......))..)).(((((((.((((((((((((((.....)))))).....((((((((..((((((.((((.......((((((((((((.(((((((...((((......)))).(((.((..((((((((((..((...((((((.....))))))..))..))))))).)))....)).))).((((.....(((((((...(((((......)))))....)))))))))))))))))).))))).(((((.....)))))(((...)))..))))))))))).))))))....)))))))).....)))))))))))))))..)))))..))))).(((((((.(((((((....)))).....)))..)))))))........................
Thermodynamic Ensemble Prediction
,((,({(..(((({(((((..(((((.(((.{.............}}...,.))))))))..))))).....(((((((((......).)))))))).....,,..{{..,...}}..)),(((((((.((((((((((((((,...,)))))).....((((((((,.((((((.((((.......((((((((((((.(((((((...((((......)))).,((|{{..((((((((((..{(...((((((.....))))))..}}..))))))))}})..,,)).))).((((.....(((((((...(((((......)))))....)))))))))))))))))).))))).{((((.....))))}(((...)))..))))))))))).)))))).}..)))))))).....)))))))))))))))..,)))}..})))).{|||||{.{((((((,...}}}}...,,|||,.}}})})),,,.........,,,,.,,,....

Transcripts

ID Sequence Length GC content
NM_001321065.2 NCBI
GAGCUCGGCUCUUGAGACAGGAAUCUUGCCCAUUCCCCGAACGAAUAAA… 553 nt 0.5497
NM_001321066.2 NCBI
GAGCUCGGCUCUUGAGACAGGAAUCUUGCCCAUUCCCCGAACGAAUAAA… 615 nt 0.5545
NM_001379687.1 NCBI
CCUGAUAAAGGUCCUGCGGGCAGGACAGGACCUCCCAACCAAGCCCUCC… 595 nt 0.5529
NM_001645.5 NCBI
AGGCGGUCAGGGGAAGGCUCAGGAGGAGGGAGAUCAACAUCAACCUGCC… 514 nt 0.5778
Summary

This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]

Forensic Context

A study in human blood plasma demonstrated that the APOC1 is a protein significantly downregulated with age, and it was used alongside other proteins and small RNAs to build age-predictive models, with a combined proteomic and miRNA model achieving an R² of 0.70 ± 0.01 [Salignon et al. DOI:10.18632/aging.204787]. In human corpus cavernosum tissue, the APOC1 was identified as a gene marker defining the APOC1+ fibroblast subclusters FB1 and FB2, with its expression pattern used to classify cellular heterogeneity [Zhao et al. DOI:10.1038/s41467-022-31950-9].