Basic Information

Symbol
APOC3
RNA class
mRNA
Alias
Apolipoprotein C3 Apolipoprotein C-III Apo-CIII ApoC-III APOCIII Apo-C3 ApoC-3
Location (GRCh38)
11:116827019-116833343
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000040.3
Sequence length
535.0 nt
GC content
0.5907

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-205.70 kcal/mol
Thermodynamic ensemble
Free energy: -214.67 kcal/mol
Frequency: 0.0000
Diversity: 131.92
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((.(((((...((((((...((.((((((.....((.((...(((((...(((....))).))))).)))))))))).))((((((((((((.........)))))))).))))))))))........((((((((........))))))))...................))))).)))))))))(((((((((((.((((((((....(((((.((((((((((((........)).)))).))))))...((((...(((((.((.....))....)))))...))))...((((((((....(((((((....((....((((....))))..)).))))))).....)))))))).)))))....))).)))).).))))))((((....(((((((.(((((....))))).)))))))......((((.((((((...)))))).))))...(((...(((((((((.......))))))))).)))...))))....((((........)))))).))).
Thermodynamic Ensemble Prediction
(((((((((.(((((...((((((...((.((((((.....((,((...{{{{|,,,(((,,,.}}}.}}})},)))))))))).))((((((((((((.........)))))))),})))})))))........((((((((........))))))))..,,..........},...))))).))))))))){{{((((((({{{(((((((,...(((((.{{{(((({((({,.,,..,,||||||||,}}}}}..,|{{{,}}|||||.{|,,..,||{{.,|}}}}},.}))))}.((((((((....(((((((,,..,,....((({....)))).,}}.))))))).....)))))))).)))))....}}}.)))).),)))})}{(((....(((((((.(((((....))))).)))))))......((((.((((({...}))))).))))..,|||,,.(((((((((.......))))))))).,))...,}}}....{(((........)))))).}}}.

Transcripts

ID Sequence Length GC content
NM_000040.3 NCBI
CUGCUCAGUUCAUCCCUAGAGGCAGCUGCUCCAGGAACAGAGGUGCCAU… 535 nt 0.5907
Summary

This gene encodes a protein component of triglyceride (TG)-rich lipoproteins (TRLs) including very low density lipoproteins (VLDL), high density lipoproteins (HDL) and chylomicrons. The encoded protein plays a role in role in the metabolism of these TRLs through multiple modes. This protein has been shown to promote the secretion of VLDL1, inhibit lipoprotein lipase enzyme activity, and delay catabolism of TRL remnants. Mutations in this gene are associated with low plasma triglyceride levels and reduced risk of ischemic cardiovascular disease, and hyperalphalipoproteinemia, which is characterized by elevated levels of high density lipoprotein (HDL) and HDL cholesterol in human patients. This gene and other related genes comprise an apolipoprotein gene cluster on chromosome 11. [provided by RefSeq, Sep 2017]

Forensic Context

No relevant information is available at the moment.