Basic Information

Symbol
MAL
RNA class
mRNA
Alias
Mal, T Cell Differentiation Protein (MAL Blood Group) Myelin And Lymphocyte Protein MVP17 VIP17 T-Lymphocyte Maturation-Associated Protein Mal, T-Cell Differentiation Protein Mal, T Cell Differentiation Protein HLD28
Location (GRCh38)
2:95025677-95054932
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002371.4
Sequence length
1084.0 nt
GC content
0.5563

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-372.00 kcal/mol
Thermodynamic ensemble
Free energy: -389.66 kcal/mol
Frequency: 0.0000
Diversity: 211.64
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...((((((((((.((((.......)).)).))))))))))((((((((((((......(((((..(((((((..((((((...((((((.(((((...(((((((((((((((....)))))(((.(((((...(((((.(((((...(.(((((...((((.........))))......))))).)..))))).)))))..(((((((.((.....)).(((((((((...)).)))))))(((((....((((..((...((((((((..(((((.....(((((.((....(((...........)))...)).))))).(((((((((.(((.((((.((((((((((.............)))))...........((((.(((((.......))))).)))).......((((..(((.((.((((.((((.((.((((...(.(((....))).).))))))))))...........))))..)))))....)))))))))...))))..)))...........)))))))))......)))))))))))))..))..)))).)))))...(((....))))))))))(((((.((.(((((..((.(((...))).))..)))))...)).))))).......................................)))))))))))))))))).))))).))))))...........))))))....)))).))).)))))(((..((.((............)).))...)))(((.((.((((((..(((((.........))))).(((((((((((((..((.(....).))..))).)))..))))))).......))))))..)).)))....((((.((((...((.((.((((....)))))).))....))))))))))))))))...((((.((((((((((((.((((((((((((((...)))).))))))))))))))))..........((((((....)))))).)))))).)))).((((....((((((....))))))...)))).....))))..
Thermodynamic Ensemble Prediction
...{(((((((((.((((.......)).)).)))))))))|((((((((((((......{{{,{{.(((((((..((((((.,.((((((.(((((...(((((((((((((((....)))))(((.(((((...(((((.(((((...,.(((((...((((.........))))......))))).}..))))).)))))..(((((((.((.....)).(((((((((...)).)))))))(((((....{(((..({...((((((((..(((((.....(((((.((..,.(((.,,.....,..))),..)).))))).(((((((((,({({(,{{.,{|||{||{,........||,,{||||,...........,(((.(((((.......))))).)))}..,,.,,{{{(,.(({{((.((((.{{{{.{{.((((.,,{.(((....}}}.}.)))))))))),..........))))..)))))....}))))),}}.},)))),,|{{,......}}}.)))))))))......)))))))))))))..))}}})),.)))))...(((....))))))))))(((((.((.(((((..((,((,...,}}.))..)))))...)).))))).......................................)))))))))))))))))).))))).))))))...........))))))....))))}})).}}|||((({{(.{(,{........,,,||.|,.{.{({(,({,(.{(((((,.(((((.........))))).(((((((({((((,,((.(....,.})..))},))}..))))))).......|,,,,)}},,})))}}.,)|}))))}....{{.{{.{{{{.,..))}}}}.})}})))))))}),))))))))...((((.((((({(((((,{((((((((((((((...)))).)))))))))))))))}..........((((((....)))))),)))))).)))|.({{{....((((({....})))))...)))).....)))),.

Transcripts

ID Sequence Length GC content
NM_002371.4 NCBI
ACUGGGCUCCGCGGAGCCAGCGAGAGGUCUGCGCGGAGUCUGAGCGGCG… 1084 nt 0.5563
NM_022438.3 NCBI
ACUGGGCUCCGCGGAGCCAGCGAGAGGUCUGCGCGGAGUCUGAGCGGCG… 958 nt 0.5511
NM_022439.3 NCBI
ACUGGGCUCCGCGGAGCCAGCGAGAGGUCUGCGCGGAGUCUGAGCGGCG… 916 nt 0.5469
NM_022440.3 NCBI
ACUGGGCUCCGCGGAGCCAGCGAGAGGUCUGCGCGGAGUCUGAGCGGCG… 790 nt 0.5392
Summary

The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]

Forensic Context

No relevant information is available at the moment.