Basic Information

Symbol
MAP2
RNA class
mRNA
Alias
Microtubule Associated Protein 2 MAP2A MAP2B MAP2C Microtubule-Associated Protein 2 MAP-2
Location (GRCh38)
2:209423988-209734235
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001375505.1
Sequence length
9650.0 nt
GC content
0.4210

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
- kcal/mol
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
-

Transcripts

ID Sequence Length GC content
NM_001039538.2 NCBI
AGUCUGGGGCGGGCGCUCGGGCUGCGCGGGCUCUGGGCAGCAGCAGCAG… 5846 nt 0.4032
NM_001363910.2 NCBI
AGUCUGGGGCGGGCGCUCGGGCUGCGCGGGCUCUGGGCAGCAGCAGCAG… 9638 nt 0.4212
NM_001363911.2 NCBI
ACACACAGACACGAGCUGGUGGCUUGCAGACUGCGUCUGUCUGGAGCUA… 9507 nt 0.4191
NM_001363913.2 NCBI
AUUCAUAGGCUGAUAGACUCGACUCCUGGGGACACACUUGGAUGGAGGC… 5409 nt 0.3945
NM_001375474.1 NCBI
AGUCUGGGGCGGGCGCUCGGGCUGCGCGGGCUCUGGGCAGCAGCAGCAG… 5753 nt 0.4031
NM_001375493.1 NCBI
AGUCUGGGGCGGGCGCUCGGGCUGCGCGGGCUCUGGGCAGCAGCAGCAG… 5673 nt 0.4026
NM_001375494.1 NCBI
AGUCUGGGGCGGGCGCUCGGGCUGCGCGGGCUCUGGGCAGCAGCAGCAG… 1557 nt 0.5055
NM_001375495.1 NCBI
AGUCUGGGGCGGGCGCUCGGGCUGCGCGGGCUCUGGGCAGCAGCAGCAG… 5924 nt 0.4011
NM_001375496.1 NCBI
AGUCUGGGGCGGGCGCUCGGGCUGCGCGGGCUCUGGGCAGCAGCAGCAG… 5843 nt 0.4030
NM_001375497.1 NCBI
AGUCUGGGGCGGGCGCUCGGGCUGCGCGGGCUCUGGGCAGCAGCAGCAG… 5579 nt 0.4011
Showing 1 to 10 of 58 entries
Summary

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

Forensic Context

A study in human postmortem brain tissue identified molecular networks associated with lifetime alcohol consumption, where the MAP2 was positively coexpressed with SCN4B isoforms in the alcoholic prefrontal cortex [Farris et al. DOI:10.1038/Mp.2014.159]. In a separate human model, MAP2 was validated as a neuronal characterization marker via positive immunofluorescent staining in induced pluripotent stem cell-derived neurons [Mendez et al. DOI:10.3389/Fpsyt.2023.1070556]. A study in mouse fetal cortical-derived neural stem cells demonstrated that ethanol exposure increased expression of the MAP2 mRNA, a neuronal maturation marker, and this increase was mimicked by overexpression of the mOct4pg9 ncRNA [Salem et al. DOI:10.1016/J.Ntt.2020.106943].