Basic Information

Symbol
MAP2
RNA class
mRNA
Alias
Microtubule Associated Protein 2 MAP2A MAP2B MAP2C Microtubule-Associated Protein 2 MAP-2
Location (GRCh38)
2:209423988-209734235
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001375505.1
Sequence length
9650.0 nt
GC content
0.4210

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
- kcal/mol
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
-

Transcripts

ID Sequence Length GC content
NM_001375508.1 NCBI
AGUCUGGGGCGGGCGCUCGGGCUGCGCGGGCUCUGGGCAGCAGCAGCAG… 5675 nt 0.4014
NM_001375509.1 NCBI
AUUCAUAGGCUGAUAGACUCGACUCCUGGGGACACACUUGGAUGGAGGC… 5634 nt 0.3962
NM_001375510.1 NCBI
AUUCAUAGGCUGAUAGACUCGACUCCUGGGGACACACUUGGAUGGAGGC… 5751 nt 0.3947
NM_001375526.1 NCBI
AUUCAUAGGCUGAUAGACUCGACUCCUGGGGACACACUUGGAUGGAGGC… 9477 nt 0.4175
NM_001375527.1 NCBI
AUUCAUAGGCUGAUAGACUCGACUCCUGGGGACACACUUGGAUGGAGGC… 9474 nt 0.4175
NM_001375528.1 NCBI
AUUCAUAGGCUGAUAGACUCGACUCCUGGGGACACACUUGGAUGGAGGC… 9465 nt 0.4177
NM_001375529.1 NCBI
AUUCAUAGGCUGAUAGACUCGACUCCUGGGGACACACUUGGAUGGAGGC… 5406 nt 0.3944
NM_001375530.1 NCBI
ACACACAGACACGAGCUGGUGGCUUGCAGACUGCGUCUGUCUGGAGCUA… 5448 nt 0.3968
NM_001375531.1 NCBI
ACACACAGACACGAGCUGGUGGCUUGCAGACUGCGUCUGUCUGGAGCUA… 9762 nt 0.4217
NM_001375532.1 NCBI
ACACACAGACACGAGCUGGUGGCUUGCAGACUGCGUCUGUCUGGAGCUA… 5650 nt 0.3933
Showing 21 to 30 of 58 entries
Summary

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

Forensic Context

A study in human postmortem brain tissue identified molecular networks associated with lifetime alcohol consumption, where the MAP2 was positively coexpressed with SCN4B isoforms in the alcoholic prefrontal cortex [Farris et al. DOI:10.1038/Mp.2014.159]. In a separate human model, MAP2 was validated as a neuronal characterization marker via positive immunofluorescent staining in induced pluripotent stem cell-derived neurons [Mendez et al. DOI:10.3389/Fpsyt.2023.1070556]. A study in mouse fetal cortical-derived neural stem cells demonstrated that ethanol exposure increased expression of the MAP2 mRNA, a neuronal maturation marker, and this increase was mimicked by overexpression of the mOct4pg9 ncRNA [Salem et al. DOI:10.1016/J.Ntt.2020.106943].