Basic Information

Symbol
MAP2
RNA class
mRNA
Alias
Microtubule Associated Protein 2 MAP2A MAP2B MAP2C Microtubule-Associated Protein 2 MAP-2
Location (GRCh38)
2:209423988-209734235
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Sudden death from CNS diseases
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001375505.1
Sequence length
9650.0 nt
GC content
0.4210

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
- kcal/mol
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
-

Transcripts

ID Sequence Length GC content
NM_001375556.1 NCBI
AGCAUUCAAGGGUGGAUCUGCAGAAAAUCACACAGCCUCACUGCGAAGC… 9120 nt 0.4160
NM_001375557.1 NCBI
AGCAUUCAAGGGUGGAUCUGCAGAAAAUCACACAGCCUCACUGCGAAGC… 9108 nt 0.4162
NM_001375558.1 NCBI
AGCAUUCAAGGGUGGAUCUGCAGAAAAUCACACAGCCUCACUGCGAAGC… 9117 nt 0.4159
NM_001375559.1 NCBI
AGCAUUCAAGGGUGGAUCUGCAGAAAAUCACACAGCCUCACUGCGAAGC… 9105 nt 0.4161
NM_001375583.1 NCBI
AGUCUGGGGCGGGCGCUCGGGCUGCGCGGGCUCUGGGCAGCAGCAGCAG… 5582 nt 0.4013
NM_002374.4 NCBI
ACACACAGACACGAGCUGGUGGCUUGCAGACUGCGUCUGUCUGGAGCUA… 9519 nt 0.4188
NM_031845.3 NCBI
ACACACAGACACGAGCUGGUGGCUUGCAGACUGCGUCUGUCUGGAGCUA… 5451 nt 0.3970
NM_031847.3 NCBI
ACACACAGACACGAGCUGGUGGCUUGCAGACUGCGUCUGUCUGGAGCUA… 5544 nt 0.3972
Showing 51 to 58 of 58 entries
Summary

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010]

Forensic Context

A study in human postmortem brain tissue identified molecular networks associated with lifetime alcohol consumption, where the MAP2 was positively coexpressed with SCN4B isoforms in the alcoholic prefrontal cortex [Farris et al. DOI:10.1038/Mp.2014.159]. In a separate human model, MAP2 was validated as a neuronal characterization marker via positive immunofluorescent staining in induced pluripotent stem cell-derived neurons [Mendez et al. DOI:10.3389/Fpsyt.2023.1070556]. A study in mouse fetal cortical-derived neural stem cells demonstrated that ethanol exposure increased expression of the MAP2 mRNA, a neuronal maturation marker, and this increase was mimicked by overexpression of the mOct4pg9 ncRNA [Salem et al. DOI:10.1016/J.Ntt.2020.106943].