Basic Information

Symbol
MAP4K2
RNA class
mRNA
Alias
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 GCK RAB8IP BL44 MAPK/ERK Kinase Kinase Kinase 2 MEK Kinase Kinase 2 EC 2.7.11.1 MEKKK 2 B Lymphocyte Serine/Threonine Protein Kinase B Lymphocyte Serine/Threonine-Protein Kinase Germinal Centre Kinase (GC Kinase) Rab8 Interacting Protein Rab8-Interacting Protein Germinal Center Kinase GC Kinase EC 2.7.11
Location (GRCh38)
11:64784918-64803241
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_004579.5
Sequence length
7147.0 nt
GC content
0.5406

Transcripts

ID Sequence Length GC content
NM_001307990.2 NCBI
GCGCCGCCCCGCGCCGGCUCCGCAGCUCGCGCCCGCCCGCCUGCCGGCC… 7123 nt 0.5402
NM_004579.5 NCBI
GCGCCGCCCCGCGCCGGCUCCGCAGCUCGCGCCCGCCCGCCUGCCGGCC… 7147 nt 0.5406
Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Forensic Context

A scoping review of human twin studies found that the MAP4K2 was mentioned in the introduction and discussion as a gene for which decreased DNA methylation was associated with higher birth weight in a singleton epigenome-wide association study meta-analysis, but it was not studied in the twin research included in this review [Dany Laure Wadji et al. DOI:10.1371/journal.pone.0315549].