Basic Information

Symbol
MDK
RNA class
mRNA
Alias
Midkine MK NEGF2 Neurite Outgrowth-Promoting Factor 2 Neurite Growth-Promoting Factor 2 Amphiregulin-Associated Protein Midgestation And Kidney Protein FLJ27379 ARAP Neurite Outgrowth-Promoting Protein Retinoic Acid Inducible Factor MK1
Location (GRCh38)
11:46380756-46383837
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002391.6
Sequence length
830.0 nt
GC content
0.6217

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-334.30 kcal/mol
Thermodynamic ensemble
Free energy: -348.67 kcal/mol
Frequency: 0.0000
Diversity: 173.19
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((((.(((..((...(((((..(.(((.(((((.((.......)))))))(.((((((((.(((.((((.(((((((((((((.((((...(((.(.(((((((.((.((((..(((((((.((((.((((((((((.((((((.(((((((........................)))))))))))).).)))))).)..)))))))(((((((.......)))))))..(((.((.(((.(((((((((((((...((((..((((((((((((((((((..(...(((((((((((....))))).)))))).)..)).)))))).)))((((.........)))).....(((..(((((.((((.......)))).)))))..)))))))..)))..))))......(((((((......))...))))).))))))...)))))))..))).)).)))....................(((....)))......))).))))..))))...)).)..)))))).).)))..(((((.(.((((((((((((.((((((((.................))))))))...)))))))..))))).).)))))))))))))))).)))...........))).)))).))))))))))).)......))))..)))))..))..)))..(((((((((((((((((.((((((((..(....((..........)).....)..)))))))))))....)))))))))))))).............................)))))...............
Thermodynamic Ensemble Prediction
.....(({..(((,,,....{({(({{(.,,|||||((.({(((..((((..((.(.((((((((.(((.((((.(((((((((((((.((((...(((,(.((((((,,({.((((..(((((((,((((.(((((((({(.((((((.(((((((........................)))))))))))),).)})}))})}.})}))))(((((((.......)))))))..(((.((.{((.(((((((((((((.,.((((..((((((((((((((((((..{.,.(((((((((((....))))),,))))).)..)).)))))).))),,{{,,,.,....,}}},,...(((..(((((.((((.......)))).)))))..)))))))..}))..))))......(((((((......))...))))).)))))),..})))))).,)),.)).)))....................(((....)))......))),})))..))))...)}.}..))))))}).)))..(((((.{.((((((((((((.((((((((.................))))))))...})))))}.,))))).).)))))))))))))))).))),..........})).)))).))))))))))).).}),..))))..)))),..,,}})}...(((((((((((((((((.((((((((.{(,{..{,..........)).....,..)))))))))))....))))))))))))))...,,,,..,,...{,......{{,.......}},.,,}}},.......

Transcripts

ID Sequence Length GC content
NM_001012333.3 NCBI
AGACCGGUUCUGGAGACAAAAGGGGCCGCGGCGGCCGGAGCGGGACGGG… 957 nt 0.6437
NM_001012334.2 NCBI
GUGCUCCCGGAAAGGCACUGGGCGACCGCACCCGUGGCUUUCUCUGGGC… 1015 nt 0.6138
NM_001270550.1 NCBI
AAUGAAAGUGAAAGAGGGGUGGGGCGGGGGCGAGCCCGGGUUCUGUGGC… 1194 nt 0.6080
NM_001270551.3 NCBI
AGACCGGUUCUGGAGACAAAAGGGGCCGCGGCGGCCGGAGCGGGACGGG… 1128 nt 0.6569
NM_001270552.3 NCBI
AGACCGGUUCUGGAGACAAAAGGGGCCGCGGCGGCCGGAGCGGGACGGG… 662 nt 0.6057
NM_002391.6 NCBI
AGACCGGUUCUGGAGACAAAAGGGGCCGCGGCGGCCGGAGCGGGACGGG… 830 nt 0.6217
Summary

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

Forensic Context

A study in rats demonstrated that the MDK (Mdk) was significantly upregulated in fetal cardiac fibroblasts compared to neonatal cardiac fibroblasts, indicating its role in developmental processes [Perreault et al. DOI:10.1152/physiolgenomics.00074.2021].