This gene encodes menin, a tumor suppressor associated with a syndrome known as multiple endocrine neoplasia type 1. Menin is a scaffold protein that functions in histone modification and epigenetic gene regulation. It is thought to regulate several pathways and processes by altering chromatin structure through the modification of histones. [provided by RefSeq, May 2019] CIViC Summary for MEN1 Gene
Forensic Context
A study in rats demonstrated that sarin-induced seizure onset triggers significant transcriptional changes in the piriform cortex, with MEN1 being up-regulated, peaking at 6 hours in microarray analysis and at 3 hours in multiplexed PCR validation [Spradling et al. DOI:10.1186/1742-2094-8-83].