Basic Information

Symbol
MGST1
RNA class
mRNA
Alias
Microsomal Glutathione S-Transferase 1 MGST-I GST12 PMAN Peritoneal Metastasis Associated Long Noncoding RNA Microsomal GST-1 Microsomal GST-I EC 2.5.1.18 MGST Glutathione S-Transferase 12
Location (GRCh38)
12:16347115-16609259
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_020300.5
Sequence length
925.0 nt
GC content
0.3870

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-205.60 kcal/mol
Thermodynamic ensemble
Free energy: -225.37 kcal/mol
Frequency: 0.0000
Diversity: 339.91
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((......((.(((......)))))))))).(((.(((((.((((((((((((..(((.(((.....((.((((..((((((.((((((((((((.....))))...(((((..(((((.......)))))..))))).......)))))))).))))))....((((((...((((.(((((.(.(..((((...(((((.((((((...)))))).))))).))))..).))))))...((((((..........))))))((((.....(((((..((((.....(((((.(((((.((((((......(((((((..............((((((.....))))))((((....((((......(((.(((....))).))))))))))).....)).)))))....)))).))..)))))..))))).....)))).....))))).....)))).(((((.(((.((((((...)))))))))))))).(((((((.......)))))))..((((((((((((....))))......)))))))).............))))))))))...)))))).((((((((....(((.(((...........)))))).)))))))).....)))))).))))))..))))))....(((.((((.....)))).)))......)))))..)))......((..((((((((((((..((((((((..(((((((....((((......(((((........)))))......))))......))))))).))))(((((((.....)))))))...............((((((......))))))....(((.((((((((........)))).))))))).....))))..)))))).))))))....)).....
Thermodynamic Ensemble Prediction
.(((((.{(...{(,({{......)))))))))).(((.(((((,{(({(((((((,.((((,({(,,,,,.{((({...,,.....,.))))}|,..,,,.,,}}}}..}))}|}},|}{(((((((((((,.((((((...)))))}..{(((((...,....}}}))}}}|,}}}))))}}{|,,({(((((((.,.(((((.(((((,...}))))).))))).},.}}}.,))))}),..{{|||{.,|,,,....|||}}}{,,{|||||||,...|||||,,,{.(((((.(({({.,(((({,.....{|{,,,,..............{(((((.....)))))}{(({...{((((......(((.(({....})).)))}}}}}}},,,||||.,|{{.(({.....))))}})))}),.)}}}),....},,}||,...,}}.,..{{{{{{,({((((((,.,(((({..{|||},,,,|||}}|,(((((((.......))))))|.{((((((({((((....}}}}......})))))}},,...,,,..}}}}}))))),})..,)))))).{{{{(({{,,|.{{{.,,,.,.........)}}},,.}))))))).....))},))))))),),,))))),...,{{{.((((.....)))),)),,,},,.}))}}..)))..,.,.|||,{{{{{{||{{||,.{{{{{{(({,,,,,,,,....,{{{{{{{{,{{{{{,.,,{{,,|||||,..|{{},,,..}},.,},,,}|{||,.(((((((.....)))))))............,..|||,||},,,,,}},}))},,,||{.(((({{((........})))|,)))||),}}..))))..)))))))}))}})...,}),,,..

Transcripts

ID Sequence Length GC content
NM_001414363.1 NCBI
AGUCCCUGCAUUGCGCGCGACCCGGCGGCGGGACAGGCUUGCUGCUUCC… 832 nt 0.3930
NM_001414365.1 NCBI
AGUCCCUGCAUUGCGCGCGACCCGGCGGCGGGACAGGCUUGCUGCUUCC… 817 nt 0.3941
NM_001414367.1 NCBI
AGUCCCUGCAUUGCGCGCGACCCGGCGGCGGGACAGGCUUGCUGCUUCC… 579 nt 0.3713
NM_001414368.1 NCBI
AGUCCCUGCAUUGCGCGCGACCCGGCGGCGGGACAGGCUUGCUGCUUCC… 941 nt 0.3858
NM_001414369.1 NCBI
AGUCCCUGCAUUGCGCGCGACCCGGCGGCGGGACAGGCUUGCUGCUUCC… 933 nt 0.3837
NM_001414370.1 NCBI
AGUCCCUGCAUUGCGCGCGACCCGGCGGCGGGACAGGCUUGCUGCUUCC… 917 nt 0.3850
NM_001414371.1 NCBI
AGUCCCUGCAUUGCGCGCGACCCGGCGGCGGGACAGGCUUGCUGCUUCC… 933 nt 0.3869
NM_001414372.1 NCBI
AGUCCCUGCAUUGCGCGCGACCCGGCGGCGGGACAGGCUUGCUGCUUCC… 915 nt 0.3847
NM_001414373.1 NCBI
AUUCUGGACCCUGAACAGGAGGGGACAUCGUGACAAAGCAAAUUGUCUG… 834 nt 0.3621
NM_001414374.1 NCBI
AGUCCCUGCAUUGCGCGCGACCCGGCGGCGGGACAGGCUUGCUGCUUCC… 823 nt 0.3815
Showing 11 to 20 of 24 entries
Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

Forensic Context

A study in mice demonstrated that the MGST1 was significantly down-regulated in cardiac tissues following myocardial infarction, as validated by qRT-PCR [Wang et al. DOI:10.1016/j.ijbiomac.2025.143171].