Basic Information

Symbol
MGST1
RNA class
mRNA
Alias
Microsomal Glutathione S-Transferase 1 MGST-I GST12 PMAN Peritoneal Metastasis Associated Long Noncoding RNA Microsomal GST-1 Microsomal GST-I EC 2.5.1.18 MGST Glutathione S-Transferase 12
Location (GRCh38)
12:16347115-16609259
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_020300.5
Sequence length
925.0 nt
GC content
0.3870

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-205.60 kcal/mol
Thermodynamic ensemble
Free energy: -225.37 kcal/mol
Frequency: 0.0000
Diversity: 339.91
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.(((((......((.(((......)))))))))).(((.(((((.((((((((((((..(((.(((.....((.((((..((((((.((((((((((((.....))))...(((((..(((((.......)))))..))))).......)))))))).))))))....((((((...((((.(((((.(.(..((((...(((((.((((((...)))))).))))).))))..).))))))...((((((..........))))))((((.....(((((..((((.....(((((.(((((.((((((......(((((((..............((((((.....))))))((((....((((......(((.(((....))).))))))))))).....)).)))))....)))).))..)))))..))))).....)))).....))))).....)))).(((((.(((.((((((...)))))))))))))).(((((((.......)))))))..((((((((((((....))))......)))))))).............))))))))))...)))))).((((((((....(((.(((...........)))))).)))))))).....)))))).))))))..))))))....(((.((((.....)))).)))......)))))..)))......((..((((((((((((..((((((((..(((((((....((((......(((((........)))))......))))......))))))).))))(((((((.....)))))))...............((((((......))))))....(((.((((((((........)))).))))))).....))))..)))))).))))))....)).....
Thermodynamic Ensemble Prediction
.(((((.{(...{(,({{......)))))))))).(((.(((((,{(({(((((((,.((((,({(,,,,,.{((({...,,.....,.))))}|,..,,,.,,}}}}..}))}|}},|}{(((((((((((,.((((((...)))))}..{(((((...,....}}}))}}}|,}}}))))}}{|,,({(((((((.,.(((((.(((((,...}))))).))))).},.}}}.,))))}),..{{|||{.,|,,,....|||}}}{,,{|||||||,...|||||,,,{.(((((.(({({.,(((({,.....{|{,,,,..............{(((((.....)))))}{(({...{((((......(((.(({....})).)))}}}}}}},,,||||.,|{{.(({.....))))}})))}),.)}}}),....},,}||,...,}}.,..{{{{{{,({((((((,.,(((({..{|||},,,,|||}}|,(((((((.......))))))|.{((((((({((((....}}}}......})))))}},,...,,,..}}}}}))))),})..,)))))).{{{{(({{,,|.{{{.,,,.,.........)}}},,.}))))))).....))},))))))),),,))))),...,{{{.((((.....)))),)),,,},,.}))}}..)))..,.,.|||,{{{{{{||{{||,.{{{{{{(({,,,,,,,,....,{{{{{{{{,{{{{{,.,,{{,,|||||,..|{{},,,..}},.,},,,}|{||,.(((((((.....)))))))............,..|||,||},,,,,}},}))},,,||{.(((({{((........})))|,)))||),}}..))))..)))))))}))}})...,}),,,..

Transcripts

ID Sequence Length GC content
NM_020300.5 NCBI
AGUCCCUGCAUUGCGCGCGACCCGGCGGCGGGACAGGCUUGCUGCUUCC… 925 nt 0.3870
NM_145764.3 NCBI
GAAUUCAAGUCCUAAAGCCUACAGUUUUGAAUACUACUGAAAUGACAAG… 910 nt 0.3604
NM_145791.3 NCBI
GGCAGAUGGAAGACUUGGGGGGGUCUCUGCCAGCUGGAAGUGCUUGGCU… 980 nt 0.3806
NM_145792.3 NCBI
AUUCUGGACCCUGAACAGGAGGGGACAUCGUGACAAAGCAAAUUGUCUG… 929 nt 0.3692
Showing 21 to 24 of 24 entries
Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]

Forensic Context

A study in mice demonstrated that the MGST1 was significantly down-regulated in cardiac tissues following myocardial infarction, as validated by qRT-PCR [Wang et al. DOI:10.1016/j.ijbiomac.2025.143171].