Basic Information

Symbol
MGST2
RNA class
mRNA
Alias
Microsomal Glutathione S-Transferase 2 MGST-II Microsomal Glutathione S-Transferase II Leukotriene C4 Synthase MGST2 Glutathione Peroxidase MGST2 Microsomal GST-II Microsomal GST-2 GST2 EC 2.5.1.18 EC 1.11.1.- EC 4.4.1.20
Location (GRCh38)
4:139665768-139741884
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002413.5
Sequence length
740.0 nt
GC content
0.4527

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-207.40 kcal/mol
Thermodynamic ensemble
Free energy: -220.88 kcal/mol
Frequency: 0.0000
Diversity: 131.33
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((.((..((((((((........)))))(((((((.((.(((((((...((((.((((((......((((((....((((.....(((((..((.(((((.((..(((((((.....)))))))..))...((.(((........)))))(((((((.((((..((.(.(((........))).))).)))).))))))).(((((((.((((((((((((.((((............))))..))))))).....((((((((((..........)))))))))).............((((((((((((((...((((....)))).((((((((.....)))))))).....((((((...((((((.((((((..((((((((((...))))))))))...)))))).))))))....))))))......))).)))))...))))))..((((.((......))))))((((((((....))))))))............)))))...)))))))))))).))..)))))(((((((..((((((...(((((((...)))))))...((.....))..(((((((....)))))))..))))))..)))))))..)))))))))).......)))))).))))..............)))))))..........)).)))))))....)))..))((((((.......))))))))))))))......
Thermodynamic Ensemble Prediction
{(((((((.,,..,,.(((((........))))),((((((((,.,{((((...})))|.((((((.((((({....})))))..)))))}..........,||....,,.,..|}.....},}...)))))))},,((.(((........)))))(((((((.((((,.((.(.(((........))).))).)))).))))))).((((((..,,,..(((((((.((((............))))..)))))))..,,,.....(((((((((((...(((((.((((..((({.....((((,,(((((((({{{,,,|||||,(((((((.((.((,{{(((......{(((....((((((,.,((((((.((((((..((((((((((...))))))))))...)))))).)))))).,,.)))))))))))))).)),}).))))))).,,.....,((((((....,,,,((((((((....)))))))).,,.......}))).}},}||||....))))).{{||,||..(((((((..((((((...(((((((...)))))))...((.....))..(((((((....)))))))..))))))..)))))))..}}.}))))}},,,,.,...))))..)))).)))))...)))))))))))).))))))((({{{..,....})))))....{(((({.......}})}}})))))))}......

Transcripts

ID Sequence Length GC content
NM_001204366.2 NCBI
AUAAAGAUCUGUGACCGGCAGCCCCAGACCUGCCUGCCUUCCUGACUUC… 1227 nt 0.4825
NM_001204367.2 NCBI
AUAAAGAUCUGUGACCGGCAGCCCCAGACCUGCCUGCCUUCCUGACUUC… 1127 nt 0.4862
NM_001204368.2 NCBI
AUAAAGAUCUGUGACCGGCAGCCCCAGACCUGCCUGCCUUCCUGACUUC… 669 nt 0.4619
NM_002413.5 NCBI
AUAAAGAUCUGUGACCGGCAGCCCCAGACCUGCCUGCCUUCCUGACUUC… 740 nt 0.4527
Summary

The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]

Forensic Context

A study in rats demonstrated that acute ethanol exposure induces an open chromatin state at the promoter of the MGST2 in the amygdala, as identified by ATAC-seq analysis [Krishnan et al. DOI:10.1038/S41380-022-01732-2].