Basic Information

Symbol
MIF
RNA class
mRNA
Alias
Macrophage Migration Inhibitory Factor GIF Phenylpyruvate Tautomerase GLIF Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) Glycosylation-Inhibiting Factor L-Dopachrome Tautomerase L-Dopachrome Isomerase MMIF Epididymis Secretory Sperm Binding Protein EC 5.3.3.12 EC 5.3.2.1
Location (GRCh38)
22:23894372-23895227
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002415.2
Sequence length
557.0 nt
GC content
0.6589

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-240.60 kcal/mol
Thermodynamic ensemble
Free energy: -247.83 kcal/mol
Frequency: 0.0000
Diversity: 72.21
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....(((((.((....)).)))))...((.((((((((((.(.((((((......)))))).).))((((((.((((((.....((((((((.((((((((((..........((((.(((((.(((((......(((.((..((((((......))))))..)).)))(((((.((..(((...)))..))....)))))....))))).))))))))).((((((((.....)))..))))).(((((....)))))(((((.(((....))).))))))))))))))).))).))))).((((((...(((((...(((((.(((((...))))).)))))...))))).)))))).(((((.((((((((((((...(((............)))..(((((.....(((((((((.....)))).....)))))...)))))..))))))....)))))).)))))......))))))))))))))).))))).))((((((((......(((((.((....)))))))..........)))))))).....
Thermodynamic Ensemble Prediction
.,,.(((((.((....)).)))))...((.((((((((((,({((((({......,))))).}.))|{((((.((((((.....((((((((.((((((((((..........(((,{(((((.(((((......(((.((..((((((......))))))..)).))){{{((.({..(({...))}..)),...))}))....))))).))))))))).((((((((.....)))..))))).(((((....)))))(((((.(((....))).))))))))))))))).))).))))).((((((...(((((...(((((.(((((...))))).)))))...))))).)))))).,((((.((((((((((((...{{,............}),..(((((.....(((((((((.....)))).....)))))...)))))..))))))....)))))).))))}......))))))))))))))).))))).))((((((((......((((,,((....)))))))..........)))))))).,,..

Transcripts

ID Sequence Length GC content
NM_002415.2 NCBI
AGUGGUGUCCGAGAAGUCAGGCACGUAGCUCAGCGGCGGCCGCGGCGCG… 557 nt 0.6589
Summary

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

Forensic Context

A study in mice demonstrated that the MIF is a pleiotropic cytokine mediating inflammatory responses through receptor complexes including CD74, CD44, CXCR2, and CXCR4 [Tao et al. DOI:10.1007/s10753-025-02346-w].