Basic Information

Symbol
MND1
RNA class
mRNA
Alias
Meiotic Nuclear Divisions 1 GAJ Meiotic Nuclear Division Protein 1 Homolog Meiotic Nuclear Divisions 1 Homolog (S. Cerevisiae) Meiotic Nuclear Divisions 1 Homolog Homolog Of Yeast MND1
Location (GRCh38)
4:153344623-153415118
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032117.4
Sequence length
929.0 nt
GC content
0.3929

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-228.20 kcal/mol
Thermodynamic ensemble
Free energy: -245.76 kcal/mol
Frequency: 0.0000
Diversity: 179.68
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...(((.((...((((((((.(((...((....))..))).))))))))................(((((((((((((............)).)))((((((((((((..(((........))).))))))).............((((.......)))).........(((((..((.((....((((((...(((....)))...(((((((((((((((((..((((.(((((((((...(((((((((((((((......(((((((.......)))))))(((......)))......)))))))))))))))..))))....((((((((((((...(((((.(((.(((((........((((((.....((((....))))))))))....((......))....))))).))).....))))))))).)))).))))...........(((...(((....(((......)))...........((((((...))))))........))).)))......((((((.......)))))).)))).).))))....((((((((((((.....((((((.(((((......))))).))..)))).................(((((((....))))))).((((.(((((((.((.........)).)).))))).))))..........)))))))))))).........))))))))).)))))))).))))))...)).)).)))))....((((((((..(((((((((.......)))))))))..)))))))).((((((..(((......)))))))))..((((((..((((....))))..))...))))))))).....(((.........)))......)))))))).)).)))...............
Thermodynamic Ensemble Prediction
...(((.{,...((((((((.{((...((....)).,)}).))))))))................(((((((((({.{,...........,}|}},((((,(((((((..(((........))).))))))).,}},.....,{(((((.......})))..,.,....(((((..((.({....{(((({...{,,....}}}...(((((((((((((((((.,((((.(((((((((...(((((((((((((((......(((((((.......))))))){{{......,}}...,,.)))))))))))))))..)))),{{{,((((((({,,(.,,.,,,,.|||.,,|||.}}}}..}||,,,({{{{{(((....{{||{(,,,||....{{......},..,.,))))}),,....}))))))))}|||||..|,|{...,|.....{||...|||.,,,||{......|||,.....}}},.((((({...))))))........}}}.}))......((((((.......)))))).}))).}.)))),...((((((((((((.....((((,({(({((,.....)))})}))}.)))).................(((((((....))))))).((((.((((({{.((.......,.)).}},))))).))))..........)))))))))))).........))))))))).)))))))).}}))))..,}}.}}.)))))....((((((((..(((((((((.......)))))))))..)))))))).((((((..(((......)))))))))..{|||((,,({{{....}}}}..,},..)))},,,,...,..|||.........}}}.,,}..)))))))).)).))}...............

Transcripts

ID Sequence Length GC content
NM_001253861.1 NCBI
AGUCGGCGCCAAAAUCAAACGCGUCCUGGCCUGUCCCGCCCCUCUCCCC… 830 nt 0.4012
NM_032117.4 NCBI
CCCUCUCCCCAAGCGCGGGCCCGGCCAGCGGAAGCCCCUGCGCCCGCGC… 929 nt 0.3929
Summary

The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]

Forensic Context

A study in human traumatic brain injury (TBI) patients demonstrated that the MND1 was one of the four most significantly down-regulated mRNAs in TBI tissue compared to adjacent control tissue [Yang et al. DOI:10.4103/1673-5374.247467].