Basic Information

Symbol
MOBP
RNA class
mRNA
Alias
Myelin Associated Oligodendrocyte Basic Protein Myelin-Associated Oligodendrocyte Basic Protein
Location (GRCh38)
3:39467172-39529479
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses Mechanical injury analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001393704.1
Sequence length
848.0 nt
GC content
0.5637

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-262.20 kcal/mol
Thermodynamic ensemble
Free energy: -278.32 kcal/mol
Frequency: 0.0000
Diversity: 213.81
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
........(((((.(((((....((((((.((((((...(((((....(((((..(((..((..........................))........(((......)))...)))..))))).)))))))))))...........((((((.((.....(((((....((((((((...))))))))...((((((((((......................(((((((...((((((((.((((((........).)))))...))))).)))...(((((...)))))...((((((((((((...)))))...((((.(((((((...(((((.((((...((..(((....((........)).....)))..))...)))).).))))....)))(((((.......(((((((((.(((((((((....(((.(((......))).)))))).))))(((((.(((......(((.((.((((((.((((((.(((......))).)).)))))).)))))).)))......))).)).))).((((.....))))..((.......)))).))))))))).......))))))))).))))..............))))))))))))))..((((...))))((((((....))).)))(((....)))......)))))).)))))))))...))))))))...............((((((....((((((((.(((.....))).))))))))...)))))).......(((........)))............)))))).))))).)))))........................
Thermodynamic Ensemble Prediction
........(((((.(((((....((((((.((((((...(((({....(((((..(((..,,.................,...,,....}........(((......))).,,)))..))))).))))))))))).........,,(,(((({(,{.{{,...(({{,.((((((((...))))))))...{(((((((((.....{,....,}}.,......{(((((({{{{,((((((.((((((........)}}))))...))))),)))...(((((...)))))...((((((((((((...)))))...((((.(((((((..,{(({(,{,((,..,{..{,{,,|..,..},.,,.)}.}}..)))}}))}..||||....}},...})},(((((.......(((((((((.(,((,,,,|}...{{{.(((......|||.||,((({{(,((((((.(((......|||.||.||||||.||||||.|||......))).)).||||}|,||||||.|||......))).)).)))}||,}}})},.,,,...,,,...}.)))}.))))))))).......)))))}}},.))))....,......,..)))))))))))))|{{({,...|,)))|,,(((....))).|((((,...)))),.....)))))).)))},|({|..,}})}............,,,,...((((((....((((((((.(((.....))).))))))))...))))))......}))))...}}}.).)}}}}}.......)))))).))))).)))))....,,,,........,,,,},..

Transcripts

ID Sequence Length GC content
NM_001278322.2 NCBI
AAACCCUCAGGGACCUGGUAUAGACGCAGAAUCUGUUUCACACAACAAC… 3390 nt 0.5097
NM_001278323.2 NCBI
AAACCCUCAGGGACCUGGUAUAGACGCAGAAUCUGUUUCACACAACAAC… 764 nt 0.5877
NM_001393704.1 NCBI
AAACCCUCAGGGACCUGGUAUAGACGCAGAAUCUGUUUCACACAACAAC… 848 nt 0.5637
NM_182935.4 NCBI
AAACCCUCAGGGACCUGGUAUAGACGCAGAAUCUGUUUCACACAACAAC… 2976 nt 0.4845
Summary

Predicted to be a structural constituent of myelin sheath. Predicted to be involved in nervous system development. Predicted to be located in mitochondrion and perinuclear region of cytoplasm. Implicated in frontotemporal dementia. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in Sprague Dawley rats demonstrated that adolescent morphine exposure in females leads to transgenerational attenuation of morphine self-administration and relapse-like behavior in offspring, with RNA sequencing and qPCR analysis identifying dysregulation of the MOBP gene (Mbp) in the nucleus accumbens, showing downregulation in F1 males and females and sex-specific changes in the F2 generation [Fair M. Vassoler et al. DOI:10.1016/j.neuropharm.2016.10.006]. A separate review notes that the MOBP can be identified in serum and cerebrospinal fluid to evaluate injury severity and correlate with morbidity and mortality following traumatic brain injury in humans [Annunziato Mangiola et al. DOI:10.1155/2015/736104].