Basic Information

Symbol
MRPS6
RNA class
mRNA
Alias
Mitochondrial Ribosomal Protein S6 MRP-S6 RPMS6 C21orf101 BS6m 28S Ribosomal Protein S6, Mitochondrial Small Ribosomal Subunit Protein BS6m S6mt Mitochondrial Small Ribosomal Subunit Protein BS6m Chromosome 21 Open Reading Frame 101
Location (GRCh38)
21:34073224-34362252
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Forensic psychiatry evaluation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_032476.4
Sequence length
931.0 nt
GC content
0.4748

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-275.10 kcal/mol
Thermodynamic ensemble
Free energy: -293.00 kcal/mol
Frequency: 0.0000
Diversity: 233.88
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((..(((((..(((...)))..))))).)))..(((((((((((((((((((((.((((((..(((.((((((((..((((....((((.(....).))))(((...(((.........))).)))))))..)))...(((((((.......))))))).(((((((.......)))))))(((........)))))).)).)))...))))).).).)))....))))).))))))))))))....((.(((((..((((((((((....(.((((((((((....((.((((.((((((..((((.........((((.((....)).))))..))))..))))))...)).)).))((((....).)))........((((((.((((((((..............))))))))....((((.........(((((.(((((((...)))))))..)))))...........))))........((((((...(((((.(((.((....)).)))...)))))......)))))))))))))))))))...))))...)))))))....)))..))))).))((((((((((((((.((((((.(.((((..(((((....(((((..........)))))......(((((((.((((((((((((.(((((......((((.....)))).....))))).))...((((((....)))))).(((((((...(((.((......)).))))))))))........((((....))))..))))))))))..))))))).(((((((..((....))..)))))))..)))))..)))).).)))))))))))..........((((.....))))...)))))))))....((((((.((((((.....))))))..)))))).
Thermodynamic Ensemble Prediction
(((,,(((((,,{(({..}}},,))))},}}}.,(((((((((((((((((({({.((((((,,(((.,,{{{{{{..{|(|,..|||{((({,..,.))))|{,.,.{{(..,,,..,,||}.,|||}}|,{||}.||(((((((.......))))))).(((((((,....,.)))))))|,,........)},))}.,).))),..)}})),}.).))},..}))))).)))))))))))).,|||(,{{{{(.,({{(((((((...,{.{{{(((((({...,((.({({.((((((..((((.........((((.((....)).)))),.))))..))))))...)).)),))}.||,{,{{{||}..,....,{{(({(,((((((((.....,,....,,,))))))))....((({.,,......(((((.(((((((...)))))))..)))))......,,...}))}........{{{{{{..,(({{{,{{{,||,,..}),})}.,})))}}.,,,..}}}}}}}))))})))))))...))})...)))))))....)))..))))}.)){((((.{..(((((.((((((.(.((((..(((({...,,((((,.........))))),.....(((((((.((((((((((((.(((((......((((.....)))).....))))).))...{(((({....})))),.{,,,{||,,{(((.((......)).))))))||},...,,,..{(((....)))}..))))))))))..))))))).((((((({.((....)).})))))))..}))))..)))).).)))))))))))..}.))))}.,,,,....,||||,,..,}}.}}},}...{{{{{{.{{{{({.....)))))}..)))))}.

Transcripts

ID Sequence Length GC content
NM_032476.4 NCBI
GCUUUCGCCGCCUGGGAGCCGUCCGGCGCAGCAGUUUCUAGGUCCCCAC… 931 nt 0.4748
Summary

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human postmortem dorsolateral prefrontal cortex demonstrated that MRPS6 expression was lower in individuals with major depressive disorder compared to non-psychiatric controls [Pantazatos et al. DOI:10.1038/mp.2016.130].