Basic Information

Symbol
MT1B
RNA class
mRNA
Alias
Metallothionein 1B MT1Q Metallothionein 1Q Metallothionein-1B Metallothionein-IB MT-1B MT-IB MT1 Metallothionein 1B (Functional) MTP
Location (GRCh38)
16:56651886-56653204
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005947.3
Sequence length
393.0 nt
GC content
0.5038

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-108.80 kcal/mol
Thermodynamic ensemble
Free energy: -115.23 kcal/mol
Frequency: 0.0000
Diversity: 113.98
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....................((.(((.((((((.(((..((((((.(((((((((((.((((.(((....)))..)))).(((....))).((((((.....))))))..(((((..((....))..))))).((.((((....))))))...))))).(((((((.((((((....((((..(((((............)))))))))((((((((((.((((.((.(((.(......).))).)).))))..))).(((((.......))))))))))))...))))))..)))))))..))))))...............(((......)))..............))))))..))).))))))))).))....................
Thermodynamic Ensemble Prediction
.,{,,...........{,..,{,{{{.{(,,,,.,,({{(,((,..,||||||,,|,.{(((.(((....)))..)}},.(((....))).((((((.....))))))..(((((..((....))..))))).,({((((....)))},)}..|||||,{({{{{{.,|||||}||.((((..{((((...,,...,...))))))))){{{((({,,,.||||.{{.{{{,|,,,,..}.)||,|},}}}}.{||{{(((((.......)))))))))))...,)})))).,|||}}},..})))),...............{{{......)))..,...........,,}}}}..,,,.,)))))|||.||,..........,}}..,,..

Transcripts

ID Sequence Length GC content
NM_005947.3 NCBI
AUCACACCUUCCUCCUGCCCUGACUUCUCAUAUCUUGCCUAGGAACUCC… 393 nt 0.5038
Summary

The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]

Forensic Context

A study in human HT-29 colorectal adenocarcinoma cells demonstrated that the MT1B was induced 17.39-fold by arsenic trioxide exposure, with dose-dependent upregulation confirmed by qRT-PCR [Kazuta et al. DOI:10.1016/J.Legalmed.2026.102774]. The research systematically evaluated cellular responses to heavy metals, revealing that the expression of the MT1B and other metallothionein genes was regulated in a metal-specific manner, providing a new perspective for metal toxicity assessment. A study in mice demonstrated that the MT1B was commonly up-regulated more than 2-fold in liver tissue after in vivo irradiation of Kupffer and endothelial cells with α-particles, a characteristic response to radiation exposure compared to hepatotoxicants [Roudkenar et al. DOI:10.1269/jrr.07078].