Basic Information

Symbol
MT1E
RNA class
mRNA
Alias
Metallothionein 1E MTD Metallothionein-1E Metallothionein-IE MT-1E MT-IE MT1 Metallothionein 1E (Functional) Metallothionein D
Location (GRCh38)
16:56625475-56627112
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001363555.2
Sequence length
746.0 nt
GC content
0.5322

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-254.20 kcal/mol
Thermodynamic ensemble
Free energy: -267.07 kcal/mol
Frequency: 0.0000
Diversity: 216.84
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....((..((.........))..))(((((.(((.((.(((((((((.((.((((.......)))).)).((((.((((.(((((((((..((....((((.(...(((((.(((((..((....))..)))))....)))))...)))))....))...)))))).)))..))))))))....(((((..((.(((.(((((((((((((((((((((((((.((....)).)))))...)))))))((((((..((((.......))))....((((((((((.............(((((((((((((........)))))))))).))).............)))))...........(((..((...((((((.((..(((((((...(((((.((.........)).))))).....)))))))..)).))))))))..))).....)))))((((((((..((((.......)))).))))))))............)))))).((((((..((((((.((((((((((((.(((((..(......)..))).))))))))...)))))).))).)))..))))))(((((.(((.....))).))))).......((((.(((...(((......))).)))..))))...............)))).)))))))))..))).)).))))))))))))))....)).))).))))).....................
Thermodynamic Ensemble Prediction
.....((.........,,..},..}}(((((.(((.((.(((((((((,{{.((((.......)))).||.{(((.((((.(((((((((||({,,..((({{(...(((((.(((((..((....))..))))}..,.||||}...))))),..,))...}))))).)))..)))))))).,|,{({{{.,||,(((.(((((((((((((((((((((((((.((....}),)))))...))))))|((({({..((((.......))))...,|,|||{.{{..,{{{{.{..{{{((,{(((((((((........)))))))))|,|||.........,{{((.,{,....},,,.{{{.{,{.....,|||{{,||..{{{{{{|,,,{|{{{.||......,,,,}.}||||.{{.,|||}}}}.,)),))})))))..))),...,|||}|((((((((..{(((.......}))).})))}}})...,,,}},....,,,,},{(((((..((((((.(((((({(((((.,,(({..{....,,),.))).}}))))))...)))))).))).)))..))))))|||||,|||}..,.)))})}})).......((((.(((...(((......))).)))..)))),{{{,....,}},,.)))).)))))))))..))).)}.}}}},,}})))))}....}).))).))))).....................

Transcripts

ID Sequence Length GC content
NM_001363555.2 NCBI
AUUCUGCUUUCCAACUGCCUGACUGCUUGUUCGUCUCACUGGUGUGAGC… 746 nt 0.5322
NM_175617.4 NCBI
AUUCUGCUUUCCAACUGCCUGACUGCUUGUUCGUCUCACUGGUGUGAGC… 398 nt 0.5000
Summary

Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human HT-29 colorectal adenocarcinoma cells demonstrated that the MT1E was induced 6.62-fold by arsenic trioxide exposure, with its expression peaking at 5 µM, and also showed a peak in expression at 10 µM cadmium chloride, indicating metal-specific regulation [Kazuta et al. DOI:10.1016/J.Legalmed.2026.102774]. Furthermore, a meta-analysis of human lung scRNA-seq data identified the MT1E as a top up-regulated differentially expressed gene in a specific monocyte subcluster from COPD patients, associating it with responses to heavy metal cations [Lee et al. DOI:10.1016/j.compbiomed.2023.107685]. A study in mice demonstrated that the MT1E was commonly up-regulated more than 2-fold in liver tissue after in vivo α-particle and γ-ray irradiation, a characteristic response distinguishing radiation exposure from chemical hepatotoxicants [Roudkenar et al. DOI:10.1269/jrr.07078].