Basic Information

Symbol
MT1F
RNA class
mRNA
Alias
Metallothionein 1F Metallothionein-1F Metallothionein-IF MT-1F MT-IF MT1 Metallothionein 1F (Functional)
Location (GRCh38)
16:56657640-56660698
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005949.4
Sequence length
425.0 nt
GC content
0.5294

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-131.20 kcal/mol
Thermodynamic ensemble
Free energy: -140.09 kcal/mol
Frequency: 0.0000
Diversity: 87.39
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.....(.(((((((((((.(((((((((((.((.(((................((......)).........(((.((......)).)))..))).))...))))))))))).)))...).))))))).)((((..(((((.((((........)))).))))).((.((((....))))))...(((.(..((((....)))))))).((((...))))(((((((((((.(..(((((((.((((((((..((((((((((.....(((((...))))).))))))))(((....))).....))...)))))))).))...............(((..............))))))))..)))))))))))).....((((....)))).....(((((.........))))).))))....
Thermodynamic Ensemble Prediction
.,,,.,.(((((((((((.(((((((((((.((.(((........,.......({......))........,(({.{{,,,,,.,,.,,,..))).))...))))))))))).))}...).))))))|{|(({,..{((((,(((({{.{{...,)),}))))).,|,{{((....)))}}},..(({.{..((((....)))),)}).((((...))))(((((((((((.(..((((({(,((((((((..((((((((((.....(((({...))))}.))))))))(((....))).....||,,.}))))))|.}}.....,||.......}||...........,,,},,)))))..)))))))))))).....,{{,....))},.....(((((.........))))).,}}}.,,.

Transcripts

ID Sequence Length GC content
NM_001301272.2 NCBI
AUCAAAGCAGCGGCCGGCUGUUGGGGUCCACCACGCCUUCCACCUGCCC… 467 nt 0.5353
NM_005949.4 NCBI
AUCAAAGCAGCGGCCGGCUGUUGGGGUCCACCACGCCUUCCACCUGCCC… 425 nt 0.5294
Summary

Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human HT-29 colorectal adenocarcinoma cells demonstrated that the MT1F was highly induced (138.6-fold) by arsenic trioxide exposure, with dose-dependent upregulation confirmed by qRT-PCR [Kazuta et al. DOI:10.1016/J.Legalmed.2026.102774]. In a separate investigation of human post-mortem tissues from septic shock patients, the MT1F was found to be upregulated in the prefrontal cortex and heart [Pinheiro da Silva et al. DOI:10.1111/jcmm.17938]. A study in mice demonstrated that internal exposure to α-particles, specifically targeting Kupffer and endothelial cells in the liver, induced a characteristic inflammatory state and altered gene expression profiles [Roudkenar et al. DOI:10.1269/jrr.07078].