Basic Information

Symbol
MT1G
RNA class
mRNA
Alias
Metallothionein 1G MT1K Metallothionein-1G Metallothionein-1K Metallothionein-IG MT-1G MT-1K MT-IG MT1 Metallothionein 1K MT1M
Location (GRCh38)
16:56666730-56668069
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001301267.2
Sequence length
410.0 nt
GC content
0.5293

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-122.10 kcal/mol
Thermodynamic ensemble
Free energy: -131.49 kcal/mol
Frequency: 0.0000
Diversity: 70.29
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...........((((((....(((................((((((((.(....(((((((.((((((.(((.(((......(((.((((.(((((.((((((((((.....))))))))((.(((((.......((((.((.((((....))))))..))))....)))))))(((...(((.(((((..((((............))))))))).)))...))).)).))))).)))).)))....))).))))))))).).))))))......).))))))))..(((..(((((....(((((...(((((((....((.....))...))))))).....)))))..)))))..))).....)))...))))))...............................
Thermodynamic Ensemble Prediction
...........(((((({,..,,,,},.............((((((((.,.,,.(((((({.((((({{(((.{((.,..,.(((.((((.(((((.((((((((((.....))))))))(,{(((((.{.....((((.,({((((....))))})}.))))....)))))))(((...(((.(((({,.((((........,,..))))))))).)))...))).)).))))).)))).)))|..}))}.))))))))).).))))))}}....}.))))))))..,,,..(((((....(((((...(((((({....((.....}}.,.))))))).....)))))..)))))..,},.....}}).,.,}}))).........,..............,......

Transcripts

ID Sequence Length GC content
NM_001301267.2 NCBI
ACUCCGCCUUCCACGUGCACCCACUGCCUCUUCCCUUCUCGCUUGGGAA… 410 nt 0.5293
NM_005950.3 NCBI
ACUCCGCCUUCCACGUGCACCCACUGCCUCUUCCCUUCUCGCUUGGGAA… 407 nt 0.5283
Summary

Enables zinc ion binding activity. Involved in several processes, including cellular response to cadmium ion; cellular response to copper ion; and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human HT-29 colorectal adenocarcinoma cells demonstrated that the MT1G was induced 17.61-fold by arsenic trioxide exposure, with dose-dependent upregulation confirmed by qRT-PCR [Kazuta et al. DOI:10.1016/J.Legalmed.2026.102774]. In a separate human study, the MT1G was identified as a differentially expressed factor in the serum of sepsis patients compared to healthy volunteers, with its mRNA expression pattern consistent with corresponding protein levels [Wang et al. DOI:10.2147/IDR.S380137]. A study in mice demonstrated that the MT1G was commonly up-regulated more than 2-fold in liver tissue after in vivo exposure to α-particles and γ-rays, a characteristic response to radiation compared to hepatotoxicants [Roudkenar et al. DOI:10.1269/jrr.07078].