Basic Information

Symbol
MT1H
RNA class
mRNA
Alias
Metallothionein 1H Metallothionein-1H Metallothionein-IH Metallothionein-0 MT-1H MT-IH MT-0 MT1 Testicular Tissue Protein Li 123
Location (GRCh38)
16:56669814-56671129
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005951.2
Sequence length
397.0 nt
GC content
0.5214

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-122.20 kcal/mol
Thermodynamic ensemble
Free energy: -128.57 kcal/mol
Frequency: 0.0000
Diversity: 78.12
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...........((((((((.(((........(((((((.((..((((...((((((((.(...((...(((.(((...)))..))).)).).)))))))).(((......)))(((((..((....))..)))))....((((....)))).)))))).)))))))(((.((((((((((((.((((((((............))))))))..)))...))..))))))).)))......(((((.(((((.((((....)))))))))...))))).(((.(((((..(((((....(((((.....(((.................)))......)))))..))))).))))).)))))).))))))))..........................
Thermodynamic Ensemble Prediction
...........((((((((.(((.....(((((((,,,{((..((({.{,((((((((.(...((...(((.(((...)))..))).)).).)))))))).)|,}}}}},||,,{{{{..{(,,,{||{.|||||....((((....)))).....((((.(.((((....)))).).)))).((((((((............)))))))).})))}.}))}.}))))))..))))))).(((((.(((((.((((....)))))))))...))))},(((.(((((..(((((....(((((.....(((.,............,,.)))......)))))..))))).,)))),)))))).))))))))..........................

Transcripts

ID Sequence Length GC content
NM_005951.2 NCBI
ACCACGCCCUCCACGUGUUCCACUGCCUCUUCUCUUCUCGCUUGGGAAC… 397 nt 0.5214
Summary

Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human HT-29 colorectal adenocarcinoma cells demonstrated that the MT1H was induced 80.9-fold by arsenic trioxide exposure, with dose-dependent upregulation confirmed by qRT-PCR [Kazuta et al. DOI:10.1016/J.Legalmed.2026.102774]. In mice, radiation exposure from α-particles and γ-rays commonly up-regulated Metallothionein 1 genes in liver tissue, a characteristic response compared to chemical hepatotoxicants [Roudkenar et al. DOI:10.1269/jrr.07078].