Basic Information
MANE select
Summary
Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in several diseases, including MELAS syndrome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; Parkinson's disease; and multiple sclerosis. [provided by Alliance of Genome Resources, Jul 2025] CIViC Summary for MT-ND1 Gene
Forensic Context
A study in human blood samples stored at 4°C demonstrated that the transcript MT-ND1 was one of 11 continuously upregulated transcripts identified as a potential time-marker for determining the time since deposition (TSD) of bloodstains [Zhang et al. DOI:10.1016/j.forsciint.2024.111930]. In a separate human study of sepsis, analysis of mitochondrial gene variants, including MT-ND1, revealed no statistically significant associations with sepsis outcome [Tsalik et al. DOI:10.1186/s13073-014-0111-5]. A study in Piophila casei sequenced and analyzed its complete mitochondrial genome, identifying 13 protein-coding genes including the MT-ND1 [Bi et al. DOI:10.3390/genes14040883].