Basic Information

Symbol
MT-ND2
RNA class
mRNA
Alias
Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 2 ND2 MTND2 NADH-Ubiquinone Oxidoreductase Chain 2 NADH Dehydrogenase Subunit 2 NAD2 Mitochondrially Encoded NADH Dehydrogenase 2 Complex I ND2 Subunit NADH Dehydrogenase 2 EC 7.1.1.2 EC 1.6.5.3 NADH2
Location (GRCh38)
MT:4470-5511
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
-
Sequence length
- nt
GC content
-
Summary

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in Leber hereditary optic neuropathy; multiple sclerosis; myocardial infarction; neurodegenerative disease (multiple); and urinary bladder cancer. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in human blood samples stored at 4°C demonstrated that the transcriptome degradation pattern could be divided into four distinct stages (days 0-2, 4-14, 21-56, and 84-168) [Zhang et al. DOI:10.1016/j.forsciint.2024.111930]. A study in Piophila casei demonstrated that the MT-ND2 exhibited the greatest variability (Pi = 0.269) among the 13 mitochondrial protein-coding genes in a 26-species comparison, indicating weak stability and suitability for evolution of variation studies [Bi et al. DOI:10.3390/genes14040883].