Basic Information

Symbol
MT-ND3
RNA class
mRNA
Alias
Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 3 ND3 MTND3 NADH-Ubiquinone Oxidoreductase Chain 3 NADH Dehydrogenase Subunit 3 NAD3 Mitochondrially Encoded NADH Dehydrogenase 3 Complex I ND3 Subunit NADH Dehydrogenase 3 EC 7.1.1.2 EC 1.6.5.3 NADH3
Location (GRCh38)
MT:10059-10404
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
-
Sequence length
- nt
GC content
-
Summary

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in Leber hereditary optic neuropathy; Leigh disease; and Parkinson's disease. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans using RNA-sequencing of serum identified the MT-ND3 (MT-ND3) as a differentially expressed mRNA that was significantly downregulated in sepsis patients compared to healthy controls [Yu et al. DOI:10.1016/j.heliyon.2023.e15034]. A study in Piophila casei demonstrated that the MT-ND3 exhibited the greatest genetic variability (Pi = 0.120) in a direct comparison between P. casei and the morphologically similar Piophila megastigmata [Bi et al. DOI:10.3390/genes14040883].