Basic Information

Symbol
MT-ND4
RNA class
mRNA
Alias
Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 4 ND4 MTND4 NADH-Ubiquinone Oxidoreductase Chain 4 NADH Dehydrogenase Subunit 4 NAD4 Mitochondrially Encoded NADH Dehydrogenase 4 Leber Optic Neuropathy Complex I ND4 Subunit NADH Dehydrogenase 4 EC 7.1.1.2 EC 1.6.5.3 NADH4 LHON
Location (GRCh38)
MT:10760-12137
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Time since deposition estimation Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
-
Sequence length
- nt
GC content
-
Summary

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in Leber hereditary optic neuropathy; Parkinson's disease; macular degeneration; and schizophrenia. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in Piophila casei (Diptera: Piophilidae) sequenced and analyzed its complete mitochondrial genome, identifying the MT-ND4 as one of 13 protein-coding genes used for phylogenetic analysis [Bi et al. DOI:10.3390/genes14040883].