Basic Information

Symbol
MT-ND5
RNA class
mRNA
Alias
Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 5 ND5 MTND5 NADH-Ubiquinone Oxidoreductase Chain 5 NADH Dehydrogenase Subunit 5 NAD5 Mitochondrially Encoded NADH Dehydrogenase 5 Complex I ND5 Subunit NADH Dehydrogenase 5 EC 7.1.1.2 EC 1.6.5.3 NADH5
Location (GRCh38)
MT:12337-14148
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Time since deposition estimation
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
-
Sequence length
- nt
GC content
-
Summary

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Part of respiratory chain complex I. Implicated in Leber hereditary optic neuropathy; Leigh disease; and MELAS syndrome. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in mice demonstrated that the MT-ND5 was downregulated in endothelial cells during myocardial infarction progression, as identified through single-cell RNA sequencing analysis [Mao et al. DOI:10.1016/j.bbrc.2025.151820]. A review of omics techniques in forensic entomology notes that the MT-ND5 is a mitochondrial gene that plays an important role in insect species identification for necrophagous species of forensic importance [Shao et al. DOI:10.1016/j.actatropica.2023.106985].