Basic Information

Symbol
MT-ND6
RNA class
mRNA
Alias
Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 6 ND6 MTND6 NADH-Ubiquinone Oxidoreductase Chain 6 NADH Dehydrogenase Subunit 6 NAD6 Mitochondrially Encoded NADH Dehydrogenase 6 Complex I ND6 Subunit NADH Dehydrogenase 6 EC 7.1.1.2 EC 1.6.5.3 NADH6
Location (GRCh38)
MT:14149-14673
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
-
Sequence length
- nt
GC content
-
Summary

Enables NADH dehydrogenase (ubiquinone) activity. Involved in mitochondrial electron transport, NADH to ubiquinone and mitochondrial respiratory chain complex I assembly. Located in mitochondrial inner membrane. Implicated in Leber hereditary optic neuropathy; Leigh disease; and spinal muscular atrophy with lower extremity predominant 2B. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in Piophila casei demonstrated that the MT-ND6 exhibited high genetic variability (Pi = 0.259) among the 13 mitochondrial protein-coding genes, identifying it as a phylogenetic marker suitable for evolutionary and comparative analyses [Bi et al. DOI:10.3390/genes14040883].