Basic Information

Symbol
MUC1
RNA class
mRNA
Alias
Mucin 1, Cell Surface Associated KL-6 PEM EMA ADMCKD1 ADMCKD Ca15-3 CD227 MCKD MCD PUM Tumor-Associated Epithelial Membrane Antigen Breast Carcinoma-Associated Antigen DF3 Peanut-Reactive Urinary Mucin Polymorphic Epithelial Mucin Carcinoma-Associated Mucin Mucin 1, Transmembrane Krebs Von Den Lungen-6 Cancer Antigen 15-3 Episialin CA 15-3 Mucin-1 H23AG MCKD1 MUC-1 PEMT Medullary Cystic Kidney Disease 1 (Autosomal Dominant) Tumor Associated Epithelial Mucin Epithelial Membrane Antigen Tumor-Associated Mucin CD227 Antigen H23 Antigen MUC-1/SEC MUC-1/X MUC1/ZD ADTKD2 MAM6
Location (GRCh38)
1:155185824-155192916
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002456.6
Sequence length
1199.0 nt
GC content
0.5513

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-446.40 kcal/mol
Thermodynamic ensemble
Free energy: -464.18 kcal/mol
Frequency: 0.0000
Diversity: 358.67
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..........(((((((.(((.((((...((((....((((((...((((.((((((.(((....(((((((((((((.(((((..............((....))..((((((((.(..((((.(((...(((((((((((.((.((((((((((...)))))))..(((((((((((((.((..(((((...(((((((........))))))).......)))))..))))))))))))))).......((((.(((((((.....((((((((.(((((....((((.(((.((.((........))...)).)))))))(((((((..(((((((...)))))))))))))).....)))))..))))))))(((.(((((...(........)...))))).)))...((.((((.(((.((((.....((((((...))))))....))))))))))).))))))))).)))).................(((((..(((..(((.....((((((((........)))))).))...))).).))..))))).......((((......))))(((((((..(((.(((((...(.((((..(((.(.((((..(((((((((....(((((....(((((.............((((((((((.(((............)))))))))))))))))).....))))))))))))))..)))).))))..)))).)..))))))))..))).)))).(((((..(((((((((((.((((.(((..((((((...))))))...)))..))))))((((.((.(((....))).)).)))).........((((((((((......))))))..)))).)))))))))))))).(((((..((((((...((....))....))))))..)))))...))))).)))))))))))..)))..))))..).))).)))))))))).)))).))))(((((....))))).(((((((.(((((((....((((.((.(((((....))))).))))))....)).))))).))))))).)))))..)))))))))..)))).))))))...))))))).).))).(((.((.(((((......))))).)))))..)))).)))........((((....))))........
Thermodynamic Ensemble Prediction
..,,,,,..,(((((((.{(({{((({,.,{{{....((((((...{(({.((((((.(((....(((((((((((((.(((((.,,,..........((.,,,|}..,,{{((((,(..(({(.{{{.,.(((((((((((.{{.,{{(((((((...}}}||||,,(((((((((((((.((..(((((...(((((((........))))))).......)))))..))))))))))))))}.......((((.(((((((.....{(((((((.(((((....{,{{,(((.{{.{{,,,,....},...}}.,},}}}}((((({{{{(((((({...}))))))))))))).....}))))..)))))))|(((,(((((...,........}...)))))})))...((.((((.((,{((((....,((((((...))))))...,))))))))))).))))))))).))))........{,......,(({((,,{{|,,{{{.....{{((((((.,,...,,)))))).))},||||,||}|,.,}}}}.,,,.,,|(((....,,)))}{((((((..(((.(((((.,.{.((((..(((.(.((((..(((((((((..,,(((((....(((((.............|(((((((((.(({.,........}.))))))))))))||)})}.....))))))))))))))..)))).)))}..)))).},.))))))))..))).)))}.((((({.,,||||||({{.((((.(((..((((((...))))))...)))..))))))|{{{.((.(((....))).)}.}}}}.,...,,,,((((((((((......)))))}.,,|||,|||||}}}}}||||}|{((({{((((((......{{{|,.....)))))})))))),}}),,},,)))}))})))),})))..))))..),))))}))))))))).)))).))))(((((....))))),(((((((.(((((((,.,.{(((.((.(((((....|)))).)))))}....}),))))).))))))).)))))..))))))))).,)))).)))))),..})))))).)}))).{{|,||,(((((......))))).}}|}}..}})),,}}.......,((((,...}})),}}}....

Transcripts

ID Sequence Length GC content
NM_001204289.2 NCBI
ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… 1094 nt 0.5676
NM_001204290.2 NCBI
ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… 1031 nt 0.5684
NM_001204291.1 NCBI
CGCUCCACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCC… 1124 nt 0.5596
NM_001204292.1 NCBI
CGCUCCACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCC… 1118 nt 0.5653
NM_001204293.2 NCBI
ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… 1077 nt 0.5469
NM_001204294.2 NCBI
ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… 1070 nt 0.5710
NM_001204295.1 NCBI
CGCUCCACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCC… 968 nt 0.5723
NM_001204296.2 NCBI
ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… 1016 nt 0.5699
NM_001204297.2 NCBI
ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… 911 nt 0.5653
NM_001371720.2 NCBI
ACCUCUCAAGCAGCCAGCGCCUGCCUGAAUCUGUUCUGCCCCCUCCCCA… 4070 nt 0.7123
Showing 11 to 20 of 21 entries
Summary

This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Forensic Context

No relevant information is available at the moment.