Basic Information

Symbol
MYL1
RNA class
mRNA
Alias
Myosin Light Chain 1 Myosin Light Chain 1/3, Skeletal Muscle Isoform MLC1/3 MLC1F MLC3F MLC-1 MLC1 Myosin, Light Polypeptide 1, Alkali; Skeletal, Fast Myosin, Light Chain 1, Alkali; Skeletal, Fast Myosin Light Chain Alkali 1/2 Myosin Light Chain A1/A2 MLC1F/MLC3F MLC1/MLC3 A1 Catalytic A2 Catalytic CMYO14 CMYP14 MYOFTA
Location (GRCh38)
2:210290150-210315174
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_079420.3
Sequence length
1049.0 nt
GC content
0.4442

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-274.60 kcal/mol
Thermodynamic ensemble
Free energy: -294.16 kcal/mol
Frequency: 0.0000
Diversity: 292.84
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...........(((((((((.........((((((((......)))........((((((...(((((((.........)))))))..))))))....(((((((((((......((.((((.......)))).))......)))))))...))))......(.(((((.(((.......))).))))).)((((..((((........))))..)))).))))).........)))))....(((((((......((.((((((......))).)))))..((((((.(((((((((((((((((((.((((((((((.......((((((((....)))))))))))).))))..)).)))).)))))((.(((((...................))))).))..((((((((.((((.....((((........))))..(((((...((((((........)))))).(((.......))).(((..((((.....(((((((((((((..(.(((((...))))).)..))))))...)))))))....)))))))..)))))..((((((((((.(((...........(((((((((...((((((....((((((((.....(.(((.((((((....(((..((((.....)))))))..))))...)).))).)....))))))))...))).))).((((.(((((((((.(((..........))).))))))))).)))))))))))))...........)))))))))))))......(((((((.(((((.((........)).))))).....)))))))..(((((....)))))...)))).)))))))).......(((((.......)))))))))))))))...((((.......))))))))))...((((((((((((((......(((.............))).....))))))).)))))))....((((........))))............................))))))).)))).
Thermodynamic Ensemble Prediction
.....,.(((((,,{(({,{,,{,...,{{|||{{{{.....,))}....|,,.,,,((({{(((((,{{.,}}},,{{||||||{{.|||||,...}}}||(((((((......,{.((((......,))}}.))......)))))))...))))},,}}}}|(((((.((({(.((,{{,}.)))))..((((..((({...,,...))))..}))).)))))...,,,,..},|},....,((((((,,{{{.,.....|||..,,{,|||....|||.(((((({(((((((((((((({,,,,,|}|||((((,...}}}}((((((((....))))))))...|{{,||,.|},|}||,|||},{{.{{{{(||.......,}.,,,....))))),)),}||..,||({(((....}}|||(,..{{{{{||||{,{{,,,,((((((((,,......}}}})))|((.......}},.((({{((((.....(((((((((((((..(.(((({...})))).)..))))))...)))))))....)))})},,,))))...((((((((((.(((..........,(((((((((...{{{(((....((((((((.....{.{((,{,{(((....(((..((((.....)))))))..)))).,.}).})).}....))))))))...))).))}.((((.(((((((((.(((..........))).))))))))).)))))))))))))...........)))))))))))))..,,,.(((((((.(((((.((........)).))))}..,..))))))).}|||{{....}||}},..,}.,,|}}}}}}}.......|||||}}}}}}.,)),,,)))))))))...((((.......))))}))))).},{(((((((((((((......(((.............))).....))))))).))))))}....((({........))))..........................,,))))))),}}},.

Transcripts

ID Sequence Length GC content
NM_079420.3 NCBI
AACACUCUGGGUCCAUCUUCAAGACACUGGGCUGUGGAUCAACCCAACC… 1049 nt 0.4442
NM_079422.3 NCBI
ACUCAGGGACCGGAGCAGCCCUCAACUCACUCUUCAGCUUCCCUGCUGU… 856 nt 0.4404
Summary

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans developed a multiplex assay for organ tissue identification, where the MYL1 was listed as a candidate mRNA marker for skeletal muscle tissue but was not mentioned in the introduction or discussion and was not experimentally studied within the described selection and validation rounds [Lindenbergh et al. DOI:10.1007/s00414-013-0895-7].