Basic Information

Symbol
MYL11
RNA class
mRNA
Alias
Myosin Light Chain 11 HUMMLC2B MRLC2 MYLPF Myosin Light Chain, Phosphorylatable, Fast Skeletal Muscle Myosin, Light Chain 11, Regulatory Fast Skeletal Myosin Light Chain 2 Myosin Regulatory Light Chain 11 MLC2B Myosin Regulatory Light Chain 2, Skeletal Muscle Isoform Myosin Regulatory Light Chain 2 Myosin Light Chain 2 HSRLC DA1C
Location (GRCh38)
16:30370332-30377991
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_013292.5
Sequence length
657.0 nt
GC content
0.5784

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-222.00 kcal/mol
Thermodynamic ensemble
Free energy: -234.35 kcal/mol
Frequency: 0.0000
Diversity: 194.97
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(.((((..(((.......))).)))).)((......)).....((((((.(((((((((((.((.....)))))).(((..((...((.((((.(((......(((((.((((((((..........(((((........)))))....(((((((((.(((((((..((((.........)))))))))))....))))).)))).(((((..((((((.(((...))).))......((((((.(((.((((((((...((........))...)))))..))))))...))))))..(((((((((......)))))))))..((((.((((....))))))))((((.(....((....((((((.((((...)))).))))))...))...)))))..))))..))))))))))))).)))))....(((.(((((....((((((....))))))........((((((((.((......))))).)))))((((....))))(((((((........)).)).)))....))))).)))..(((..((((.((((((..(((((...((((....)))))))))...)))))))))))))))).)))).)).))..)))...............)).)))))))))))..
Thermodynamic Ensemble Prediction
((((.((.((((((((({{{((((.(..((......))..}))))...}})....(((((((.(({,(((((((..{,(,,(((({{,{({(((({...,,,,,.,)))))))),,.))}}}...,.(((((........))))},.....))))))).(((((((..((((.........)))))))))))....(((((.((...,)}.,.)))}}{{.(((...))).}|((({.{.,....,.})))|.,|})).)))))))..})))))))).)).}})),,....{{{{{....(((((((((......)))))))))..(((,,((((....))))))))((((|{..,.((....((((((.((((...)))).))))))...))}}}}}))).....)}}}}{((((((((((({((((......}}))),....))))))}}}))))|((((({{.{..{{((((({,((,....,}}|}},}}}})|||||,..|||||.,,,,,........||,..{{{|.,,..,,.,))}),,)||..{((.{((((((..(((((...((((....)))))))))...))))))),))||}|}|.........,}))))}}..............})})))),}}},,,..

Transcripts

ID Sequence Length GC content
NM_001324458.2 NCBI
CCUUCUCUCUUCUUAGAGACAACAGGUGGCUGGGGCCUCAGUGCCCAGA… 843 nt 0.5848
NM_001324459.2 NCBI
AUUUAGGCGGUGACAGACAGCAUCCGCAGUCAAUAGGAAGAGCUGAAGA… 847 nt 0.5809
NM_013292.5 NCBI
GACUCCUUGCUUCUUUCCAGCCGGAGCCGCUGCCUUGCCCCCCGGAGAC… 657 nt 0.5784
Summary

Predicted to enable calcium ion binding activity. Predicted to be a structural constituent of muscle. Involved in muscle contraction. Located in lysosomal membrane. Implicated in distal arthrogryposis type 1C. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans identified the MYL11 as a gene marker highly expressed in cavernosal trabecular smooth muscle cells (CCSMC) within the corpus cavernosum, with its expression being especially elevated in patients with erectile dysfunction [Zhao et al. DOI:10.1038/s41467-022-31950-9]. In forensic science, targeted massively parallel sequencing assays have utilized the MYL11 as an mRNA marker for the specific identification of skeletal muscle tissue in human samples [Haas et al. DOI:10.1016/j.fsigen.2021.102486]. A study in mice demonstrated that the MYL11 is a protein-coding gene associated with sarcomeric function and is linked to ChIP-clusters enriched in down-regulated long non-coding RNAs following myocardial infarction [Ounzain et al. DOI:10.1093/eurheartj/ehu180]. In rats, RNA sequencing of cardiac fibroblasts across developmental ages identified the MYL11 as an RNA marker for cardiac development/function, showing it was significantly downregulated in adult cardiac fibroblasts compared to neonatal and fetal groups and was associated with the neonatal/fetal cluster in principal component analysis [Perreault et al. DOI:10.1152/physiolgenomics.00074.2021].