Basic Information

Symbol
MYL12A
RNA class
mRNA
Alias
Myosin Light Chain 12A MRLC3 MLCB MYL2B MRCL3 Myosin, Light Polypeptide, Regulatory, Non-Sarcomeric (20kD) Myosin, Light Chain 12A, Regulatory, Non-Sarcomeric Myosin Regulatory Light Chain 2, Nonsarcomeric Myosin Regulatory Light Chain MRLC3 Epididymis Secretory Protein Li 24 Myosin Regulatory Light Chain 12A Myosin Regulatory Light Chain 3 Myosin RLC HEL-S-24 MLC-2B RLC
Location (GRCh38)
18:3247481-3256260
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl UniProt GTEx

MANE select

Transcript ID
NM_006471.4
Sequence length
958.0 nt
GC content
0.4269

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-260.30 kcal/mol
Thermodynamic ensemble
Free energy: -281.88 kcal/mol
Frequency: 0.0000
Diversity: 191.57
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
........((((....))))((((.((((((((((((((((((((..((((((((((...(((((((..((((.((.(((.....))).)).))))...))..)))))....)))..)))))))..((((((((..((..((((.((............((((.....))))............)).)))))).))))))))((((((.......(((..(((...))).)))......))))))(((........)))((.(((.((..(((.((((....((((...))))...)))).)))..)).))).))..(((((((.(((((...(((((((((..(((.((((...)))).)))..)))...........(((((((....))))))).......))))))(((...))).))))))))))))...((((.((((((.((((...))))))))))..))))((.....))..).)))))).))))))))))))).)))).(((((((..(((((((((...((((((((.(.((((((((.((.......(((.((....)).)))((((((.......((((..(((.....((.(((........)))))....)))...))))..((((.....)))))))))).((..((((.....))))))..((..((((((.(.((((...))))..).))))))..)))).)))))))).).)))))))).)))))((((((((..(((......)))...((((....)))).......((((((......))))))..............))))))))...((((.........))))..))))....)))))))....(((((.....)))))...............((((((((((((........))))))))))))(((((((.......)))))))......
Thermodynamic Ensemble Prediction
......,,((((....)))}((((.((((((((((((({((((({..(((((((,,....(((((((..((({.((.(((.....))).)).)))).,.)),.}))))....},..,))))))).|{((........,..,....,,.....,,,,,,,((({.....}|||((({{,(,....}||}}}}|,.{{(((((.((((((.......(((..(({...))}.))),.....)))))).))}}},)}..|,{(|.{{|.||.,||,.|{{|..,,||||,..,})}..,)))).)))}{||.,,,,)),.(((((((.(((((.,,(((((({,((,{((.((((...)))).)))},...,,.........(((((((....))))))).......)))))),,,.,.})}.))))))))))))...((((.((((((.((((...))))))))))..))))((.....))....,))))).))))))))))))).)))).(((((((..((({(((({...((((((((.(.((((((((.,{.{{,,,.(((.((....}).)))({{((({{,....((((..{{(,....((.(((........)))))....))}...))))..||||,,...}},,,}}}}}.{{..{(((.....)))))}..{{..((((((.,.((((...))))..}.))))))..}))),)))))))).).)))))))).))))),{{{((({..(((......)))...,{,,....}}},....,.{(({{{{.||...,|},,,.......,.,,,,.)))})}},...((((.,.......))))..})))....)))))))...,(({((.....,,))},}}...........,((((((((((((........))))))))))))(((((((.......)))))))......

Transcripts

ID Sequence Length GC content
NM_001303047.2 NCBI
AAGCAGAGGCCGGAAGCGGUGGUUUUUAGCGGCUCUCUGGGUAGCAGGG… 1041 nt 0.4256
NM_001303048.1 NCBI
CGCCCUUCGCCGUGCCCUGGAAUGUGCGGCCAGGCAAAGCCACAGGACG… 974 nt 0.4158
NM_001303049.2 NCBI
GCUGCUGAGCGGUUUUGCAGACUACCAUCUUCCCUGCAACUCUGAAGGA… 900 nt 0.4078
NM_006471.4 NCBI
AAGCAGAGGCCGGAAGCGGUGGUUUUUAGCGGCUCUCUGGGUAGCAGGG… 958 nt 0.4269
Summary

This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]

Forensic Context

A study in humans analyzing peripheral blood samples via single-cell and bulk RNA sequencing identified a 13-gene prediction model (HF.Sig) for post-myocardial infarction heart failure, which included the MYL12A [Sun et al. DOI:10.3389/fimmu.2023.1163350].