Basic Information

Symbol
MYL2
RNA class
mRNA
Alias
Myosin Light Chain 2 CMH10 Myosin Regulatory Light Chain 2, Ventricular/Cardiac Muscle Isoform Myosin, Light Polypeptide 2, Regulatory, Cardiac, Slow Myosin, Light Chain 2, Regulatory, Cardiac, Slow Cardiac Ventricular Myosin Light Chain 2 Ventricular Myosin Light Chain 2 Cardiac Myosin Light Chain 2 MLC-2s/V MLC-2v MLC-2 MLC2 Myosin Light Chain 2, Slow Skeletal/Ventricular Muscle Isoform Slow Cardiac Myosin Regulatory Light Chain 2 T160D Myosin Regulatory Light Chain 2 S15D Myosin Regulatory Light Chain 2 Regulatory Light Chain Of Myosin RLC Of Myosin MFM12
Location (GRCh38)
12:110909996-111052434
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Forensic psychiatry evaluation Sudden unexpected death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000432.4
Sequence length
783.0 nt
GC content
0.5338

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-259.50 kcal/mol
Thermodynamic ensemble
Free energy: -272.59 kcal/mol
Frequency: 0.0000
Diversity: 185.70
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
((((((((.((((.((((.....((((((..(((((.(((.......)))..)))))........(((((((...(((((.(((((((....((.((((((.....)))))).)).....(((...(((..((((.(((...(((((((((((((.((........))..)))))(((((((....(((....)))......(((.(((((((((....))).)))))).)))...)))))))...(((((......)))))(((...)))((((((......(((((..((.(((((((.......)))))))..)).)))))....))))))((((((.....))))))..((((((....(((((........)))))...))))))))))))))..))).)))).)))..(((((..((((((((.((.(((((.......((.(((.(((.....))).))).))))))).)).)))).))))..))))).((((.....))))..((((((.(...((.((.((...)).)).))...).)))))).)))(((.....)))))))))).))))).))))))).(((.(((....)))))).....))))))..)))).))))))))))))..(((((..(((((((((((.(((((((..........................)))))).).)))))))((((.....(((((((.(............((((......))))).))))))).))))....)))))))))......
Thermodynamic Ensemble Prediction
((((((((.((((.{,,,..{{,((({((..((((({(((.......))).,)))))........(((((((...(((((.(((((((....((.((((((.....)))))}.}}.....(((...(((..((({.{{{...((((((({(((((.((........))..)))))(((((((....{{{....})}......(((.(((((((((....))).)))))).)))...)))))))...{((((......))))}(({,.|||}((((((..,{..(((((..{(.(((((((.......)))))))..}).))))).,,.)))))){(((((.....)))))|,,((,,,,...}|}|||,,{{{{...,,,..,}))}}}}})))))))..})}.)))).))}..(((({..((((((((.((.{{((,...|}..(({((,(((.(({.....))),))),))))})),)))).))))..})))).((((.....))))..((((((.(...((.((.((...)).)).))...).)))))).)))|{{.....})}))))))).))))).))))))).(((.(((....)))))).....,}}))),,)))}.)))))))))))),.((((,..((((({(((((.,(({(((,,,,.....,,{,{,...........),})},.)}))))}}}||||.,...||||||{,|,,..,,,...,,((((......}}}},.))}})))}}}},...}))))))))).,....

Transcripts

ID Sequence Length GC content
NM_000432.4 NCBI
GGGCGGAGUGUGGAAUUCUUCUCGGGAGGCAGUGCUGGGUCCUUUCCAC… 783 nt 0.5338
NM_001406745.1 NCBI
GGGCGGAGUGUGGAAUUCUUCUCGGGAGGCAGUGCUGGGUCCUUUCCAC… 741 nt 0.5385
NM_001406916.1 NCBI
AGUGUUCGGGACUGCCUCACGCUGUGCAGAGAAACAAAGAAGGGAGAUC… 791 nt 0.5322
Summary

This gene encodes a major sarcomeric protein in mammalian striated muscle. The encoded protein plays a role in embryonic heart muscle structure and function, while phosphorylation of the encoded protein is involved in cardiac myosin cycling kinetics, torsion and function in adults. Mutations in this gene are associated with hypertrophic cardiomyopathy 10 and infant-onset myopathy. [provided by RefSeq, May 2022]

Forensic Context

A study in humans demonstrated that the MYL2 is significantly downregulated at the RNA level in the cardiomyocytes of individuals with Sudden Unexplained Death in Schizophrenia (SUD-SCZ), where it is associated with the pathogenesis of the condition as a gene involved in cardiac contractility and calcium homeostasis [Chen et al. DOI:10.1016/J.Forsciint.2025.112646]. In a separate study in mice, the MYL2 was identified as a protein-coding gene associated with sarcomeric function and was linked to chromatin immunoprecipitation clusters enriched in downregulated long non-coding RNAs following myocardial infarction [Ounzain et al. DOI:10.1093/eurheartj/ehu180]. A study in rats demonstrated that the MYL2 (Myl2) is a cardiac development-associated RNA marker, with its expression significantly downregulated in adult cardiac fibroblasts compared to both neonatal and fetal fibroblasts, indicating its role in age-dependent transcriptomic shifts [Perreault et al. DOI:10.1152/physiolgenomics.00074.2021].