Basic Information

Symbol
MYL3
RNA class
mRNA
Alias
Myosin Light Chain 3 MLC1SB MLC1V CMH8 VLC1 Myosin, Light Polypeptide 3, Alkali; Ventricular, Skeletal, Slow Myosin, Light Chain 3, Alkali; Ventricular, Skeletal, Slow Ventricular/Slow Twitch Myosin Alkali Light Chain Ventricular Myosin Alkali Light Chain Ventricular Myosin Light Chain 1 Cardiac Myosin Light Chain 1 MLC-LV/Sb CMLC1 VLCl Myosin Light Chain 1, Slow-Twitch Muscle B/Ventricular Isoform
Location (GRCh38)
3:46835109-46885911
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000258.3
Sequence length
885.0 nt
GC content
0.5672

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-328.60 kcal/mol
Thermodynamic ensemble
Free energy: -343.90 kcal/mol
Frequency: 0.0000
Diversity: 182.74
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((((((((((((((..((((((((.((..(((((((.....(((((((((.(((((..((..(((((((.(((((.((.((....(((((..((.(((.....)))(((....)))((((((...(((((((.((((.(((((((..((((.((((((((((((.(((........)))))))))))).....(((((((..(((((..(((...)))..)))))..))))))).((((((.(((.((.((((........))))))..)))..)))))).))).))))..))))))))))))))....((((.......(((((.(((.(((.((((.(((.((..((.(((((((...((((..(((......)))...))))...))))))).))..)))))........(((........)))..)))))))....))).))))))))).)))).)))))).((((......))))))..))))))).)).))))).))).)))).......))..)))))...)))).....))))))))).))).)).)))))).))..))((((((((((.(((..((((((..(((.(((.....))).)))..))).).))..).)).))))))))))......))))..)))))))..)))((((((((.(((((((.(((((((..((((((.(((..((((....)))).((..((((((.(((..(((.......)))..))).)))))).))...(((((.((((....)))).).))))(((......)))......((((((((..(((....)))..))))).)))....)))..))))))....))))......)))))))))))))))))).
Thermodynamic Ensemble Prediction
.,((((((((((((((((..((((((((.((..(((((((.....(((((((((.(((((..{,..{((((((.(((((.{,.{(,.,.(((((..((,(((,,...||}{({....}}}((((((...(({{(((.((((.(((((((..((((.(((,{,{(((((.{{....,,}}}}}},}}},,,}}.....{((((((..(((((.,(({...}}),,)))))..))))))}.((((((.(((.((.((((........))))))..)))..)))))).))).))))..))))))))))))))..,{({,,.,.||,....((|({{.((({(((||((,{((..((.(((((((.,.((((..(((......)))...))))..,))))))).))..)))}}........{{{.......,)))}}).))))){{{{{{|...})))))).)))).)))))|{((((.....,))))))..)))))}),)).))))).))).)))).,,....})..)))))...)))).....)))))))))},)).)).))))))},)..))((((((((((.(((..((((((..(((.(((.....))).)))..))).)},)..).)).))))))))))......)))).,)))))))..)))((((((((.(((((((.(((((((..((((((.(((.,((((....))))|((,.((((((.(((..(((.......)))..))).)))))).}}...(((((.((((....)))).).))))(((,....})))......((((((((,,,,....,}}},,))))).)))....)))..))))))....))))......)))))))))))))))))).

Transcripts

ID Sequence Length GC content
NM_000258.3 NCBI
ACCCUGCUUUCUGCAUUCUUCUCUCCACAUCCCUCUCUGUACUUACAGC… 885 nt 0.5672
NM_001406937.1 NCBI
ACCCUGCUUUCUGCAUUCUUCUCUCCACAUCCCUCUCUGUACUUACAGC… 1014 nt 0.5730
NM_001406938.1 NCBI
CUCCGCAGCCGCCGACGCGGGAGUGUGGAGAGGCCGAGAGGAGCCUUCC… 1157 nt 0.5895
NM_001406939.1 NCBI
CUCCGCAGCCGCCGACGCGGGAGUGUGGAGAGGCCGAGAGGAGCCUUCC… 1039 nt 0.5871
NM_001406940.1 NCBI
AAUGUGACUUCAGCAAACACUCAGCAGCACUGCCCUGGCCCUGUGCUGU… 789 nt 0.5691
NM_001406941.1 NCBI
AAUGUGACUUCAGCAAACACUCAGCAGCACUGCCCUGGCCCUGUGCUGU… 1074 nt 0.5680
Summary

MYL3 encodes myosin light chain 3, an alkali light chain also referred to in the literature as both the ventricular isoform and the slow skeletal muscle isoform. Mutations in MYL3 have been identified as a cause of mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human cadavers demonstrated that mRNA expression of the MYL3 was significantly higher in the anterior wall of the right ventricle in sudden cardiac death cases with confirmed acute myocardial infarction compared to those without [González-Herrera et al. DOI:10.1016/j.forsciint.2019.109876]. A study in human cadavers demonstrated that the MYL3 gene exhibited significant differences in expression between postmortem interval (PMI) groups, with higher expression at longer PMI periods (>12 hours) in blood and heart tissue samples [Gonzalez-Herrera et al. DOI:10.1016/J.Forsciint.2013.08.001]. In a separate study using model organisms, linear regression analyses of gene expression groups, which included specific transcripts, provided accurate PMI predictions, with an 11-gene set in zebrafish yielding an R² of 1 and a 7-gene set in mouse liver yielding an R² of 0.98 [Hunter et al. DOI:10.1016/J.Forsciint.2017.02.027].