Basic Information

Symbol
MYL4
RNA class
mRNA
Alias
Myosin Light Chain 4 PRO1957 ALC1 AMLC GT1 Myosin, Light Polypeptide 4, Alkali; Atrial, Embryonic Myosin, Light Chain 4, Alkali; Atrial, Embryonic Myosin, Atrial/Fetal Muscle, Light Chain Atrial Myosin Light Chain 1 Myosin Light Chain 1, Embryonic Muscle/Atrial Isoform Myosin Light Chain Alkali GT-1 Isoform MLC1
Location (GRCh38)
17:47200446-47227683
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002476.2
Sequence length
855.0 nt
GC content
0.5614

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-302.30 kcal/mol
Thermodynamic ensemble
Free energy: -317.52 kcal/mol
Frequency: 0.0000
Diversity: 226.85
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
........(((((((.(((..((((...((..((((..((((.......))))...))))..))....))))....(((...)))...((((((.(((......((.(((((........((((((.(((.(((((........((.((((((...(((.(.((.((((((((((.((((((.(.((((((((....))))((((..(((.....))))))).(((..((((((((((((.((.....)).)))))))..)))))..)))......(((((..((.(((...))).))....)))))((((((((((.(((((((...(((((.(((((.((........((((((.(.((((.(((((((....))).))).......(((....))).).)))).).))))))))..))))).))))).))))))).))).))))))).....(((((..(((((((((((.....(((((....((((.(.((((...)))).).)).)).....))))))))))))))))..))))))))).))))))).((((((((.(((.....((((.((((((....(((.(((((((((.....((((......))))))))))))).))).......)))))).))))......)).).)))))))).....))))))..)))).))((.(((((((((....))))....))))).)).......).)))...)))))))))))))))).))))))....((....)).........))))))).(((.(((...))).)))..(((((....))))).........))))))))).))))))))))......
Thermodynamic Ensemble Prediction
....,,..(((((((.(((..((((...((..((((..((((.......))))...))))..))....))))....{({...}}}...((((((.(((......((.(((((....,.,,(((({{,((({(((((..({,...{{.(({(((..,(((.{,((.(|{|,(({{(,{{{{(,.(,({{({(((..,,|,.|((({,,..,.,,.,))}}}}}.(((..((((((((((((.((.....)).)))))))..)))))..)))...,..(((((.,((.(({...))).)).,..)))))((((((((((.(((((((...(((((.(((((.........,{((((((.(.((((.{((((((....))),,)),,....|,,,.....)).}.)))).).)))))).)..))))).))))).))))))).)))}}})))))..,,{(({((.{((((((({{(({,,,{{{{{(|..|((({|(.({((,{,},}}.),}}.))},.}}))}}}))}))}|||||{{,,,))))))},,}}}||{((((((((.(((.....((((.((((((...,(((.(((((((((.....((((......))))))))))))).))}.......)))))).))))......)).).))))))))..}}}))))))}},)))}))||.|||||((((....)))}....})))).}),,,,,}.}.)))...))))))))))))))}).}))|||,...||,,,.,,.........))))))).(((.(((...))).)))..(((((....))))).........)))))))))}))))))))))...,},

Transcripts

ID Sequence Length GC content
NM_001002841.2 NCBI
GUGUGAGGCUUAUCAACUGCUCAAGUCAGCUCAUCUCUCUGGCUGCUCC… 942 nt 0.5573
NM_002476.2 NCBI
AUCUCAUCUCCCAGACGCCACGUCUCUCGGUUUCUUCUUAGAUCACUCC… 855 nt 0.5614
Summary

Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in human prostate tissue from cadavers demonstrated that the MYL4 is upregulated in samples with a late ischemic time (>1000 minutes) compared to those with an early ischemic time (<150 minutes) [Javan et al. DOI:10.1038/s41598-025-29561-7]. This finding was part of a broader investigation into postmortem interval (PMI)-related gene expression, where the MYL4 was identified as a classical muscle-related gene whose increased expression is associated with longer postmortem intervals, providing molecular data relevant for PMI estimation.