Basic Information

Symbol
MYL6
RNA class
mRNA
Alias
Myosin Light Chain 6 MLC3NM MLC1SM ESMLC Myosin, Light Polypeptide 6, Alkali, Smooth Muscle And Non-Muscle Myosin, Light Chain 6, Alkali, Smooth Muscle And Non-Muscle Myosin Light Chain Alkali 3 Myosin Light Polypeptide 6 17 KDa Myosin Light Chain Myosin Light Chain A3 MLC-3 LC17 Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6 Myosin Light Chain 3 LC17-GI LC17-NM MLC3SM LC17A LC17B
Location (GRCh38)
12:56158345-56163496
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_021019.5
Sequence length
708.0 nt
GC content
0.5339

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-251.90 kcal/mol
Thermodynamic ensemble
Free energy: -264.35 kcal/mol
Frequency: 0.0000
Diversity: 137.01
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((((((((((.(((..(((((((...(((((..((.(((....((.((..((((...))))))))))).))..)))))..)).)))))))).))(((((....)))))))))))))).(.(((((.((((.....))))))))).)...((((((((.(((((((.(((.((((........)))).....))).))))......(((((((.(((((((((.....(((((((((........)))))))))......(((((.((((((((((.(((((((.(((....(((((((((((((....(((((.....((((..((.....))...))))....))))))).)))))))))))....)))....))))))))))))..((((((.((((.(.(((.(((.(((.(((..(((.((((.(((((.(((((.(((((((.(((((((...)))))))...((.((...)).)).....(((((.....)))))((((...))))...))).)))).))).)).)))...(((((.(((...)))))))).)))))).)))..))).))).))).))).).)))).))))))(((((.........))))).....)))))))))).......))))))))).)))))))..((((.....))))((((...............))))))).))))))))
Thermodynamic Ensemble Prediction
(((((((({{(.(((..(((((((...(((((..((.(((....{{.(({.,,,|}}.},,,.},,))).))..)))))..)).)))))))).}|(((((....)))))))))))))).(.(((((.((((.....)))}))))).)...((((((((.((((,{(..{{,{,,,...,{,.,|}}},,...))),}}})},....(((((((.(((((((((...{,(((((((((.,....,.))))))))).,,...(((((.(((((((((,{(((((((.(((....((((((((((({(....(((((.....((((..{(.....))...))))....))))))).)))))))))))....)))....)))))))))))).,{(((((.((((.(.(((.(((.(({.(((..(({.((((.((((((({{((.{{(((((.(((((((...)))))))...||.{{,,,,,.}),,.,|||||||....}}}}||{((((({((((....}))))).))))),}))}...(((((.(((...)))))))).)))))).)))..))).))).))).))).}.)))).)))))||((((..,......)))))}....)))))))))).......))))))))).))))))).{(,((..{,{,,,,,|||..,,.,........,,)))),,.))))))))

Transcripts

ID Sequence Length GC content
NM_021019.5 NCBI
GCCAUUACUGCAGGAAAAGGUCCCGGAGAGCUGAGCAGUCAAGAUGUGU… 708 nt 0.5339
NM_079423.4 NCBI
GCCAUUACUGCAGGAAAAGGUCCCGGAGAGCUGAGCAGUCAAGAUGUGU… 663 nt 0.5249
Summary

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain that is expressed in smooth muscle and non-muscle tissues. Genomic sequences representing several pseudogenes have been described and two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Forensic Context

A study in humans and rats demonstrated that the MYL6 is a widely distributed myofibril component serving as a marker for smooth muscle cells in the corpus cavernosum [Yin et al. DOI:10.1016/j.celrep.2024.114760]. In a separate human study, the MYL6 was identified as a highly expressed housekeeping gene exhibiting low variation across individuals, making it insensitive to factors like genetics, environment, age, and gender [Sharma et al. DOI:10.1152/physiolgenomics.00228.2003].