Basic Information

Symbol
MYL6B
RNA class
mRNA
Alias
Myosin Light Chain 6B MLC1SA Myosin, Light Polypeptide 6B, Alkali, Smooth Muscle And Non-Muscle Myosin, Light Chain 6B, Alkali, Smooth Muscle And Non-Muscle Smooth Muscle And Nonmuscle Myosin Light Chain Alkali 6B Myosin Light Chain 1 Slow A Smooth Muscle And Non-Muscle Myosin Alkali Light Chain 6B Myosin Light Chain 1 Slow-Twitch Muscle A Isoform Myosin Alkali Light Chain 1 Slow A MLC1sa
Location (GRCh38)
12:56151966-56159647
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002475.5
Sequence length
828.0 nt
GC content
0.5906

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-316.60 kcal/mol
Thermodynamic ensemble
Free energy: -335.17 kcal/mol
Frequency: 0.0000
Diversity: 215.04
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
(((.((((....(((((((.......(((((((((((((((((((((((((((((........)))).))))).(((((((...(((((((....((....))...)))))))..((......))...((((((((((.(((.(....(((((((((........)))))))))(((((....(((..........)))))))).((((((((((((((((((..(((..........(((((((((((((...(((...))).))))).((((.....))))..))))))))..))).))).))))((((..(.....)..)))))))))))))))....((((.((((.....)))))))).).))))))))))))))))))))...((((..((((((.((.(((((.(.((.((((....)))).)).)..))))).....)).))))))))))............))))))((((.(((...((..(((((.........)))))..))......))).).....))).))))))...))))))))....)))))))...)))).)))....(((((....(((((.(((.(((((.(((....))).))))).))).))))).((..((((.((.((((((((..............))).))))))).))))..))...(((((((...((......))..))).))))..(((((......((.(((((((((((...))))))))))).))....)))))))))).....((((((((..(((((..((((........)))))))))..).)))))))
Thermodynamic Ensemble Prediction
(((.((((....(((((((........(.(((((((((((((((((((((((,,,.}}}}}}.}|},.,}|||,(((((((,,.(((((((.,.,{(.....}..,))))}})}.}|,..........((((((((({{(((.{....(((((((((........)))))))))(((({...,(((..........)))))))).((((((((((((((.(((..(.......}}}.}|||,,{.((((((.,.((,...})).)))))).|....,..||}}{{{||,||||.{{||..,},))))))}.})}}}...}.,}..,}))))))))))....{(((.{(({.....)))))))).,.)))))))))))))}))))}}...((((..((((((.{{,(((((.(.((.((((....)))).)).)..))))).....}}.)))))))))).......,....))}}}}(,,..,{{,.|||,,(((((.........)))))..)).,....}}},},..}}))}.))))))}))))).)..}....)))))))...)))}.})),.,|({{(||,.|(((((.(((.(((((.(((....))).))))).))).)))}|{((,.((((.((.((((((((.,.,....,.....))).))))))).))))..}}.,.{(({{{{|||{.......,,...,|,}}}},,||{||,,.,.,||.(((((((((((...))))))))))).|||...}}}}}.}},,.}},.{{||||||,,(((((.,{(((......,,)})}))))).,)})))}))}

Transcripts

ID Sequence Length GC content
NM_001199629.2 NCBI
GCUAUGCCCCGCCCCCUCCCCAGCCCCAGACACGGACCCCGCAGGCCAA… 892 nt 0.5930
NM_002475.5 NCBI
GCUAUGCCCCGCCCCCUCCCCAGCCCCAGACACGGACCCCGCAGGAGAU… 828 nt 0.5906
Summary

Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Forensic Context

A study in humans demonstrated that in skeletal muscle from BMI-discordant monozygotic twins, the heavier co-twins exhibited lower expression of the MYL6B, a protein involved in cytoskeleton organization, as part of a broader proteomic signature associated with acquired obesity [van der Kolk et al. DOI:10.1016/j.xcrm.2021.100226].