Basic Information

Symbol
NDUFA7
RNA class
mRNA
Alias
NADH:Ubiquinone Oxidoreductase Subunit A7 B14.5a NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 7, 14.5kDa NADH Dehydrogenase [Ubiquinone] 1 Alpha Subcomplex Subunit 7 NADH-Ubiquinone Oxidoreductase Subunit B14.5a Complex I B14.5a Subunit CI-B14.5a NADH Dehydrogenase (Ubiquinone) 1 Alpha Subcomplex, 7 (14.5kD, B14.5a) Complex I-B14.5a
Location (GRCh38)
19:8308768-8321382
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005001.5
Sequence length
580.0 nt
GC content
0.5517

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-193.30 kcal/mol
Thermodynamic ensemble
Free energy: -203.67 kcal/mol
Frequency: 0.0000
Diversity: 190.71
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
......(((((((........)))))))((.((((........)))).)).((((..((((((((.(((..(((((((((((((.((((.((.(.((((....(((....))).))))).)))))).))..........)))))))))))..(((.....)))............(((((((....)))))))..))).))).....)))))..))))........((((..((((.(((((((((.((((((((((.((((...(((((((((.((.((((((.((....))..)))))).))..((((((((.((.......)).))))))))...((((....(((......(((......)))......)))...)))).........(((((((((.....)))))))))..(((.............))).....)))))))))(((((..(((...)))..))))).................(((((...)))))..............))))..))))....)))))).)).))))..))).))))..)))).(((((......)))))..
Thermodynamic Ensemble Prediction
......(((((((,....,.,|}}}})).,.||||,...,{{{((||{{,,{{,...(((,(((.{((({.((,((((((,,,..,|||}||...((((.{{{((({...|,|,||,}..,|||||{|.......{{{{.,,|||||,},...,))}}}})))......,,,...,,||||{...,|}|}|||,{{,,(((,....{{{|,,.....|.......,{,.((((((({{((,(({((,((({(((,,(((((((((....)))))))..)))))).{{.....,,,||||||}}}.,||||{{(({((,,.....}),)))))}}|{{.,..}))}.)))))..}}}))))}},))})),},.|||}},.})),.........(((((((((.....)))))))))..,||||,....,,,{|,........((((((((.(({....,,,},,)))))))).........,.........(((((,..|}}}}.,..}}}}}}..})))))}.}}}),.))))))).....})))....}},))))}.))),||||,.}}}}})))),..

Transcripts

ID Sequence Length GC content
NM_005001.5 NCBI
AGUAUCGCGGACGGAAGAUGGCGUCCGCCACCCGUCUCAUCCAGCGGCU… 580 nt 0.5517
Summary

This gene encodes a subunit of NADH:ubiquinone oxidoreductase (complex I), which is a multiprotein complex located in the inner mitochondrial membrane. Complex I functions in the transfer of electrons from NADH to the respiratory chain. [provided by RefSeq, Mar 2011]

Forensic Context

A study in mice demonstrated that NDUFA7, a hub gene related to mitochondrial oxidative respiration, was transcriptionally up-regulated in the ventral tegmental area during the addicting phase of nicotine self-administration, indicating its role in the associated mitochondrial dysfunction and energy metabolism alterations [Fan et al. DOI:10.1016/J.Jgg.2024.08.009].