Basic Information

Symbol
NDUFB11
RNA class
mRNA
Alias
NADH:Ubiquinone Oxidoreductase Subunit B11 NP17.3 ESSS Np15 NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 11, Mitochondrial NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 11, 17.3kDa NADH-Ubiquinone Oxidoreductase ESSS Subunit Complex I NP17.3 Subunit Neuronal Protein 17.3 Complex I-ESSS CI-ESSS P17.3 MC1DN30 Np17.3
Location (GRCh38)
X:47142071-47145466
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001135998.3
Sequence length
586.0 nt
GC content
0.5887

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-218.20 kcal/mol
Thermodynamic ensemble
Free energy: -229.48 kcal/mol
Frequency: 0.0000
Diversity: 115.77
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((....(((((((((((.((.((((((((((((((...((((.(((((((.((((((....)))))))))(((((((((.(((((...)))).).))))).))))((...((.((((((((..((.(((.((((((((((((......))))))...))))))..)))..))........((((((..(.(((((....(((((((((.(((.(((((((((........(((((((((.((((..............))))...))).))))))..)))))))...)).))).))))))).))(((..(((((((((((...(((((..((.....)).....))))).)))..))))))))..))).)))))))))))).....))))))))...))....))..((((((...)))))).(((...))).........)))).)))).)))).....))))))))))))))))).)))............((((((.....(......).....))))))(((((...(((...(((((.......)))))))).........))))))))...))))..
Thermodynamic Ensemble Prediction
.((((...,(((((((((((.{{.(((((((((((((({{.((((.(((((((.((((((....)))))))))(((((((((.(((((...)))).).)))))}}))}(((,.,{.((((((({,,(,.(((.((((((((((((,.....))))))...))))))..)))..}},..,,,..((((((..{.(((((,,,.{{(((((((.(((.(((((((((........(((((((((.({(({{........}}}},,)}...))).))))))..)))))))...)).))).))))))).)){((..(((((((((((...(((((..((.....)).....))))).)))..))))))))..))).)))))}))))))..,}})))))))).,.}.....,,,.{(((((...))))))}||....|||...}},...)))).)))).,))),.}.}))))))))))}}))))).))}....,,,}}...((((((....,(.,{,...,.})})))))){((((...{{{...(((((.......))))))},.,.......)))))}))...))))..

Transcripts

ID Sequence Length GC content
NM_001135998.3 NCBI
GAGACCCUGCAGCACCAUCUGUCAUGGCGGCUGGGCUGUUUGGUUUGAG… 586 nt 0.5887
NM_019056.7 NCBI
GCUCACCUUCUCGGCCCGGGCUGUCAAGGAAGGGCUCCCAGACAUCACC… 1405 nt 0.6000
Summary

The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is located at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to ubiquinone. Mutations in the human gene are associated with linear skin defects with multiple congenital anomalies 3 and mitochondrial complex I deficiency. [provided by RefSeq, Dec 2016]

Forensic Context

A study in mice demonstrated that the NDUFB11 is a nuclear-encoded mitochondrial gene marker enriched in the high-energy metabolic ventricular cardiomyocyte cluster vCM4 following myocardial infarction [Bian et al. DOI:10.3892/mmr.2025.13680].