Basic Information

Symbol
NDUFB3
RNA class
mRNA
Alias
NADH:Ubiquinone Oxidoreductase Subunit B3 B12 NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 3, 12kDa NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 3 NADH-Ubiquinone Oxidoreductase B12 Subunit Complex I-B12 CI-B12 NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 3 (12kD, B12) Complex I B12 Subunit MC1DN25
Location (GRCh38)
2:201071433-201085754
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002491.3
Sequence length
493.0 nt
GC content
0.4077

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-123.40 kcal/mol
Thermodynamic ensemble
Free energy: -134.13 kcal/mol
Frequency: 0.0000
Diversity: 110.47
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.........(((((...((((((((((..(((((((.(((.((.........)).))))))))...(((((..(((....)))..)))))...((((((..((((...))))..)))).))...((((.((...(((((..(((((((((..((.(((((........((((.((...(((((...)).))).)).))))((((.(..(((((........)))))..).)))).....(((((..((((..((((((.(((((......(((((....(((((((........(((..(((((.....))))).))).......))))))))))))......)))))))))))..))))..))))))))))))..)).))))))))))))...))))))..........))..))))))))))........(((((.....(((((.........)))))....)))))..................)))))
Thermodynamic Ensemble Prediction
.........,((((...((((((((((..((({(({{(((.((.........)).))))))}|,..(((((..(((....)))..))))).,.{{((((..((({...})))..)))}.,,...{((||({...,{((((.(((((((((..((.(((((.....,{,((((.((...((({{...}}.))).)).)))){{,,.,..||||({,,,,,|.|,,}|,.}.}})).....|||||,,|(((,,((((((.(((((......(((({...{(((((((,{{{{....||,}|{(((.....}))},..,,...,,,,})))))))))))......)))))))))))..)))),.}}}}})))))))..)).)))))))}))))...))))))......,,.,))..)))))))))).,,{,,{,{({......,|,,||}},.....,)}},|.,,,||,,...,,,.,,,,....,,,,)))),

Transcripts

ID Sequence Length GC content
NM_001257102.2 NCBI
CGUUUCCGGUUGGCUCCGGUUGCAGAGUUGAGUGUCCUGAGAGGUCAGA… 516 nt 0.4070
NM_002491.3 NCBI
CGUUUCCGGUUGGCUCCGGUUGCAGAGUUGAGUGUCCUGAGAGGUCAGA… 493 nt 0.4077
Summary

This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene. [provided by RefSeq, Mar 2012]

Forensic Context

A study in humans identified the NDUFB3 as one of the top ten most central mitochondrial genes via protein-protein interaction network analysis in sepsis patients [Li et al. DOI:10.1186/s12920-024-01891-x].