Basic Information

Symbol
NDUFB9
RNA class
mRNA
Alias
NADH:Ubiquinone Oxidoreductase Subunit B9 UQOR22 LYRM3 B22 NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 9, 22kDa NADH Dehydrogenase [Ubiquinone] 1 Beta Subcomplex Subunit 9 NADH-Ubiquinone Oxidoreductase B22 Subunit LYR Motif-Containing Protein 3 Complex I B22 Subunit CI-B22 NADH Dehydrogenase (Ubiquinone) 1 Beta Subcomplex, 9 (22kD, B22) Complex I-B22 MC1DN24
Location (GRCh38)
8:124539101-124580648
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Drug abuse diagnoses
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005005.3
Sequence length
691.0 nt
GC content
0.5297

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-236.90 kcal/mol
Thermodynamic ensemble
Free energy: -249.18 kcal/mol
Frequency: 0.0000
Diversity: 188.89
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((((((((..(((((....((((((((((........)))))))))).....)))))(((.(((((((..(((.((((((......)))))))))..)))....(((((.(((.((........)).))).)))))...((((((((.(((.((((....(((.((((.........)))))))....))))...)))))))))))....(((....)))....((...((((....)))).))...((((((.((..(((.((((....))))))).)).))))))......))))))).(((((((((.(((((.....((((......((.((.(((((.((((((......((.(((((.((((((.((....)))))))).))))).)).))))))))))))).)).....))))..)))))..))).))))))..)))))).(((....((((..((((..(((.((((..(.(..((((((..((((....)))).))))))..).)..)))).))).(((..((....)).))).....((((.(((...))).))))..))))..))))..)))(((.....)))..((((((((((((....))).)))))).)))..(((((((...((((((....)))))))))))))...............)))).......
Thermodynamic Ensemble Prediction
.{((((({{{,(({((,(,(({,(((((((((,{{{{..{{|||,|||},,((({..(((((({.{.,(((((((((.((((((......))))))))}.,{(({,..,,|||||}||((({,.{|,{((((,({.{(((((........))))))|||||,,.,{{.{{{{...,,.,,.))))})),}}})}}}}}.))))).)})})})..}..,}}})))....,,.}}}|||}..}))).|}}.|||||{{,.||,,|||},|||,...||||}||.||.}||||.(((...|{{.,...(((((((((.(((((.,...((((......((.((.(((((,{(((((......((.(((((.((((({,((....)))))))).))))).)).))))))))))))).)).....))))..)))))..))).))))))...})})).,}}}..)))))).||.}},|||...,,((({.((((((((..((((....)))).)))))...))).})))}}))},|||}}((....))..))}}}}.{(((.({,,,,,||,|||,....,,.}))}..}},}|||.,.},)}}..((((((((((((....))).)))))).)))..(((((((...((((((....)))))))))))))...............}}},..,}},.

Transcripts

ID Sequence Length GC content
NM_001278645.2 NCBI
AGUCACCCGCAGCAGGCGUGCAGUUUCCCGGCUCUCCGCGCGGCCGGGG… 656 nt 0.5381
NM_001278646.2 NCBI
AGUCACCCGCAGCAGGCGUGCAGUUUCCCGGCUCUCCGCGCGGCCGGGG… 689 nt 0.5298
NM_001311168.2 NCBI
AGUCACCCGCAGCAGGCGUGCAGUUUCCCGGCUCUCCGCGCGGCCGGGG… 658 nt 0.5380
NM_005005.3 NCBI
AGUCACCCGCAGCAGGCGUGCAGUUUCCCGGCUCUCCGCGCGGCCGGGG… 691 nt 0.5297
Summary

The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

Forensic Context

A study in humans identified the NDUFB9 as a novel genome-wide significant gene associated with the genetic predisposition to cocaine dependence in African-Americans [Huggett et al. DOI:10.1523/Jneurosci.2879-19.2020]. While not differentially expressed in postmortem prefrontal cortex neurons from individuals with cocaine use disorder, the NDUFB9 was a central entity within a robust and validated gene coexpression network associated with the disorder, with guilt-by-association analyses suggesting a potential role in cell death, synaptic plasticity, and cell adhesion.