Basic Information

Symbol
NDUFS7
RNA class
mRNA
Alias
NADH:Ubiquinone Oxidoreductase Core Subunit S7 NADH Dehydrogenase [Ubiquinone] Iron-Sulfur Protein 7, Mitochondrial CI-20 PSST NADH Dehydrogenase (Ubiquinone) Fe-S Protein 7, 20kDa (NADH-Coenzyme Q Reductase) NADH-Ubiquinone Oxidoreductase 20 KDa Subunit Complex I 20kDa Subunit Complex I-20kD PSST Subunit FLJ46880 FLJ45860 NADH Dehydrogenase (Ubiquinone) Fe-S Protein 7 (20kD) (NADH-Coenzyme Q Reductase) Complex I, Mitochondrial Respiratory Chain, 20-KD Subunit NADH:Ubiquinone Oxidoreductase PSST Subunit NADH-Coenzyme Q Reductase EC 1.6.99.5 EC 7.1.1.2 CI-20KD CI-20kD MC1DN3 MY017
Location (GRCh38)
19:1383527-1395590
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Chronological age estimation Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_024407.5
Sequence length
758.0 nt
GC content
0.6689

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-338.50 kcal/mol
Thermodynamic ensemble
Free energy: -349.50 kcal/mol
Frequency: 0.0000
Diversity: 247.51
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
......((((.(.((.((.(((((((((((.(((((...)))))..))))((((.((((....(((((((((((....))))(((((((((((((..((((..((((((((((......((((((.(((.((((....(((((.(((.(((((.(((.....))).))).))(((((((((.......(((.((.(((((.(...(((((((((((.((((((.(.....((((..((((((...((((....)))).))))))))))))))))).)))))((((((...(((.(.....).)))...)))))).((.(((((((((((((((((.(((((((((....)))))))))...)))...))))......))).))))))).)).......))).)))...).))))).)))))..(((.((((...))))...))).)))))))))...(((((...)))))))).))))))))).)))....))))))(((((((..........)))))))..((((.((((.....))))))))))))))))))...........))))....)))))))).)))))(.((((.((((........)))).)))).))))))))((((..((((.(((.((..(((((......))))).))))).))))..))))..))))))))...))))))).)).)).).))))((..(((.((((..(((((.......))))).....)))).))).)).
Thermodynamic Ensemble Prediction
{{{{{{,(((,{.(({,..((({{((((,{,(.((((((((.((((((((((({.,{{,......(((((((((....)))))))))|))))))))))))((((((({((((,...{((.(((((((({.(((((...(((({.....,.,})}.|})}....)))))..(((.(((((.(........).))))).))).......})))))))).)))}))),))))))}{,..((((((,{,((((....)))),)))))),},((((({,,,(((({.(((,(.((((((((((.{{{|,|.{({{,||...,.(((((((((((((((((.(((((((((....)))))))))...))),..)})}}..,,}})).))))))).(((.{{.{{........),)))))...{{({{{{{{{.((((...))))...))}})))))}))))},}})|)}))))))))}}))).).)))).})),))}}},,,|{((({{{..........)))))))))))))))}}))}))))),,)))||.(((({,..,{{...(((((((...{{..(((((..(((({({,((((.((((........)))).)))).}.......((((..((((.(((.((..(((((......))))).}})),,))})}})}}),)).)).))))...)))))...)}...)))))))..}))))))}}..(((((.......))))))}).)))))).......

Transcripts

ID Sequence Length GC content
NM_001363602.2 NCBI
GUCUGAAGGCCGAGGCCAAGAUGGCGGUGCUGUCAGCUCCUGGCCUGCG… 1731 nt 0.6880
NM_024407.5 NCBI
GUCUGAAGGCCGAGGCCAAGAUGGCGGUGCUGUCAGCUCCUGGCCUGCG… 758 nt 0.6689
Summary

This gene encodes a protein that is a subunit of one of the complexes that forms the mitochondrial respiratory chain. This protein is one of over 40 subunits found in complex I, the nicotinamide adenine dinucleotide (NADH):ubiquinone oxidoreductase. This complex functions in the transfer of electrons from NADH to the respiratory chain, and ubiquinone is believed to be the immediate electron acceptor for the enzyme. Mutations in this gene cause Leigh syndrome due to mitochondrial complex I deficiency, a severe neurological disorder that results in bilaterally symmetrical necrotic lesions in subcortical brain regions. [provided by RefSeq, Jul 2008]

Forensic Context

A review of human multi-omics studies for biological age estimation identified the NDUFS7 as a gene associated with epigenetic aging clocks, being part of a top list of genes linked to 11 such clocks [Solovev et al. DOI:10.1016/j.mad.2019.111192]. Separately, an experimental study in male Sprague Dawley rats demonstrated that the NDUFS7 was significantly altered in expression in liver tissue on day 4 following a 20% total body surface area burn injury, specifically within the context of mitochondrial electron transport [Jayaraman et al. DOI:10.1016/j.jss.2007.05.025].