Basic Information

Symbol
NHP2
RNA class
mRNA
Alias
NHP2 Ribonucleoprotein NOLA2 Nucleolar Protein Family A, Member 2 (H/ACA Small Nucleolar RNPs) H/ACA Ribonucleoprotein Complex Subunit 2 SnoRNP Protein NHP2 FLJ20479 NHP2 Ribonucleoprotein Homolog (Yeast) Nucleolar Protein Family A Member 2 NHP2 Ribonucleoprotein Homolog NHP2-Like Protein DKCB2 NHP2P
Location (GRCh38)
5:178149459-178153961
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Sudden cardiac death diagnosis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_017838.4
Sequence length
780.0 nt
GC content
0.5705

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-279.10 kcal/mol
Thermodynamic ensemble
Free energy: -293.02 kcal/mol
Frequency: 0.0000
Diversity: 159.19
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
....((((((...((.(((((....((.((((.((((((((((((.((.((.(((..(((...((((................))))...)))..))).)).)).)))))..))))))).))))))((((..((((((.(((((.(((.((((....)))).....(((((...((((((((((((((((.((((((.(((.(((..(((.(...(((.(((.........))).)))...).)))))).))).))))))...(.((((..((...((((((.((.(((.......((((..(((((...(((((........)))))..............))))).))))......((((..(((((.....((((((((.((((...((........)).)))).)))).)))).....)).)))..))))....))).))))))))...)).)))).).)))))))..))))).))))..)))))))).)))))...))))))..)))).((((((.........))))))(((((((((.((.((((....))).).))..)))))))))..(((((.((((((......)))))).)))))...)))))))...))))))(((((....(((((.((((.((((((.....(((..(((.....)))))).....))))))..))))((((((..((....(((.........)))....))..))))))((((...)))).)))))..)))))....................
Thermodynamic Ensemble Prediction
..,.((((((...((.(((((....{(.((((.((((((((((((.((.((,(((..(((...((((................))))...)))..)))}),.}).)))))}.})))))).)))))|((((..((((((.(((((.(((.((((....)))).....(((((...(((((((((((((((,.((((((.(((.(((.,(((.,...(((.(((.,....,..))).)))..,).)),))).))).))))))...{.((((..((...(((((,,((.(((,{,...,((({..{((((,.,(((((........))))).....,{{{,...})))}),}}}}.,,,..{|||,|||||||....,,{||||..||||...||.,,,,...}},)))}.,((((((((((...))))....))))))..))).))))))))...)).}))).}.}))))))..))))).))))..)))))))).)))))...))))))..)))),((((((.,......,)))))),((((((((.((.((((....))).).))..))))))))}..(((((.((((((......}))))).)))))...)))))))...))))))(((((,...(((((.((((.((((((.....{((,.({{.....})))}}.....))))))..)))}((((((..({....(({.|......})))..}.}}..))))))|||{...}},,.))))),,))))}{{{....}}}...,,,....

Transcripts

ID Sequence Length GC content
NM_001034833.2 NCBI
AAGUGAUGCCUAAAGCUGUGGACCGCGUGGGCUCGCCUCCCUGGGACUA… 674 nt 0.5831
NM_001396110.1 NCBI
AAGUGAUGCCUAAAGCUGUGGACCGCGUGGGCUCGCCUCCCUGGGACUA… 908 nt 0.5639
NM_017838.4 NCBI
AAGUGAUGCCUAAAGCUGUGGACCGCGUGGGCUCGCCUCCCUGGGACUA… 780 nt 0.5705
Summary

This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]

Forensic Context

A study in mice demonstrated that the NHP2 was significantly downregulated in lung tissue 48 hours after whole-body irradiation across multiple doses, identifying it as one of the most significantly downregulated mRNAs [Aryankalayil et al. DOI:10.1080/09553002.2023.2214205]. A separate review summarizing single-cell sequencing analyses in mice post-myocardial infarction reported that the NHP2 is enriched in a cycling B-cell subpopulation, marking its role in the cardiac immune response following injury [Bian et al. DOI:10.3892/mmr.2025.13680].