Basic Information

Symbol
NICOL1
RNA class
mRNA
Alias
NELL2 Interacting Cell Ontogeny Regulator 1 NICOL C4orf48 NELL2-Interacting Cofactor For Lumicrine Signalling NELL2-Interacting Cofactor For Lumicrine Signaling NELL2-Interacting Cell Ontogeny Regulator 1 Chromosome 4 Open Reading Frame 48 Neuropeptide-Like Protein C4orf48 CHR4_55
Location (GRCh38)
4:2040628-2043964
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Other applications
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_001168243.4
Sequence length
425.0 nt
GC content
0.7435

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-208.40 kcal/mol
Thermodynamic ensemble
Free energy: -214.76 kcal/mol
Frequency: 0.0000
Diversity: 84.59
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..(((((..((((((.((((((((........)).))))))..)))).(((((((((((((.((......(((((((((....(((.((......))....)))....)))))))))....)).)))))..(((.((((((((((((..(((((.((((((.((((.(.((((((((((....)))))).((((.((...)).))))((.((((......)))).))((((.(((((...((((((((((............))))))))))))).)).)))).))))).)))).)).))))..))))).))).)).)))).))).))).((.(((((...)))))))....(((((((((..(((....)))..)))))))))...)))))).)).))..))))).......((((....))))
Thermodynamic Ensemble Prediction
..(((((..({((((,(({(((((....,...)))))))}).})))).{{(((((((((((.((....,,(((((((((,,,.((,.{{...,,.))....)))....))))))))),...)).)))))..(((.((((((((((((..(((((.((((((.((((.(.(((((((({{,{,.|||||,.{{{{.{|,,,)},))})||,((((......)))).}}((((.(((((...((((((((((............))))))))))))),)).)))).))))).)))).)).))))..))))).})).)).)))).))).))).{{.(((((...)))))}}....(((((((((..(((....)))..))))))))).,.)))))).||{||{.,||||......}|||,.}}}))).

Transcripts

ID Sequence Length GC content
NM_001141936.3 NCBI
AUGCGCGUUGCGCGCCGGACGCGGAACGUCUGCCGGUGUCCCCGCGCUG… 532 nt 0.7331
NM_001168243.4 NCBI
AUGCGCGUUGCGCGCCGGACGCGGAACGUCUGCCGGUGUCCCCGCGCUG… 425 nt 0.7435
Summary

Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in 3'-UTR-mediated mRNA stabilization and spermatogenesis. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that the NICOL1 was downregulated in subcutaneous adipose tissue during short-term weight loss in healthy obese participants [Bollepalli et al. DOI:10.1038/ijo.2017.245].