Basic Information

Symbol
NINJ2
RNA class
mRNA
Alias
Ninjurin 2 Nerve Injury-Induced Protein 2 Ninjurin-2
Location (GRCh38)
12:562852-663742
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Postmortem interval inference
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_016533.6
Sequence length
918.0 nt
GC content
0.5447

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-317.60 kcal/mol
Thermodynamic ensemble
Free energy: -333.12 kcal/mol
Frequency: 0.0000
Diversity: 338.72
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
...............(((...((((((((((((((((........((((...)))))))))).(((((((.((((((.((((.(((.(((.(((((.........(((((.((((((.(((((..(((((.......)))))....)))................(((((((.......).))))))....(((((((((((((((......)))))))))..).))))))).)))))))))))..((((((((((.....((...........((((...))))..........))....)))))))))).(((((.............))))).((((.......)))))))))((((.....)))).....((((((((.((.(((((((((((........((((..((.(((((((((....(((..((((...((((....))))..(((((((.((((......(((.(((((((.(((((((((((.....(((...))))))))...)))))).)))))))..)))..((((((((....((................))....))))))))(((((.....))))).)))).)))).))).....((((.((((...)))).))))..((((((((...((((...((((((.....))))))...))))...)))...)))))...........((((((.((.....))))))))((((((.(((((((..........))))))).))))))..))))..))).(((((....))))))))))))))..))...))))....)).))))))..))).))....))))))))))).))))))...).))))))...))))))).......(((((.......)))))...))))))))))..))).
Thermodynamic Ensemble Prediction
.,,{,,,..,,.{{,((({{.{(((((((((({(({({{,,.,..((((,,.}}}))))}}).({(((((.{{((((|{{((,{(((({{,{{,{{,.{,,....||||{.,{{{{,.{{{((,,(((((......,}||||{{{,|{{,....,||,.,{,,..((((((,.......},)))}||{{{,(((((((((((((({......}))))))))..)}}))))((((({.{(.{({(,,{((({((((.....,,,,,,........,{{,,,,})|}}}}}.}}.}}))}}.,}},{{||....))}))})}}|,.,|}}||,}}||}|{(||{{{{{,|}||}||}.{{{{,...,||||||,,.,|||||||,{|,,,,{{{|{{,{..,...,,||||,,{,.,,|||||||}.},|||}}|||,...{{((....)}}}...(((({{.||||......{{{.(((((((.(((((((((((.....(((...))))))))...)))))).))))))).,))).}||||||||....||,|,,,,.,.....,},)}.,,.)))})|||{((((,....}}}}}.)))},}))),}|},,,,.{{((.((({...)))),))))},|||||,{{,|,{||{,,.(({{((...,.}}})))...}))),,.))}...}}|}|,|||},.,,,}|{{{||||{,,,.,}}))))}}((((((.(((((((..........))))))).)))))){{|,||{.||,.(({,,...}),,)).))))))||||}}.,.|||}...,},.))))),..,))}),....,,}}}))})}}}))}))))),})))))}}...}}}}}}}.......{{(({.......}}))}...)))))))},,..,,,.

Transcripts

ID Sequence Length GC content
NM_001294345.2 NCBI
AGUAAUUGCUUGGUGGGGCAAGAGGCUUCAGUUCCAAGUCAGCAAAUGG… 871 nt 0.5304
NM_001294346.2 NCBI
GUUGCAAAGCAGCCGCUCGGUGGCCGUACAACGCUUCAUCUCUCCGAGC… 926 nt 0.5421
NM_001367996.1 NCBI
GUUGCAAAGCAGCCGCUCGGUGGCCGUACAACGCUUCAUCUCUCCGAGC… 1057 nt 0.5402
NM_016533.6 NCBI
AGAGACUCAGACGGCGGAGCCUGGAGGAGCCCACGCAGUCUGUUCCCGG… 918 nt 0.5447
Summary

The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after nerve injury. [provided by RefSeq, Oct 2011]

Forensic Context

A study in Sprague Dawley rats demonstrated that the NINJ2 transcript is a potential marker for early postmortem interval (EPMI) estimation in brain tissue [Wang et al. DOI:10.1016/j.legalmed.2019.04.008]. Its expression initially increased and then decreased after death, and mathematical models incorporating temperature and postmortem interval showed it had a high coefficient of determination (>80%) and low prediction error (<3 hours) in validation experiments, with its model achieving the highest accuracy among four tested genes.