Basic Information

Symbol
NKG7
RNA class
mRNA
Alias
Natural Killer Cell Granule Protein 7 GMP-17 GIG1 Natural Killer Cell Group 7 Sequence Granule Membrane Protein Of 17 KDa Natural Killer Cell Protein 7 G-CSF-Induced Gene 1 Protein Granule Membrane Protein 17 GIG-1 Protein Protein NKG7 P15-TIA-1
Location (GRCh38)
19:51371606-51372704
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_005601.4
Sequence length
774.0 nt
GC content
0.5904

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-287.80 kcal/mol
Thermodynamic ensemble
Free energy: -299.90 kcal/mol
Frequency: 0.0000
Diversity: 262.46
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.......(((((..(((((((.(((((((((((..(((((((((..((((...))))...(((((.(((.....))).))))).......((((.(((((.((((((((((((.........)))))).(((((...)))))((....))))))))..)))))))))..((((.((......))...))))((((.....))))..)))))))))(((((((((..(((.(((((..((((((..(((((....(((...(((((((..((((((((.....((((((.((.((((.((...........)))))))))))))).))))))))..(((((......((......))........))))))))))))))).))))).))))))..))...........(((((....)))))...((((.(((((((....))))))).))))......)))))).)))))))))............)))))).............)))))))))))).....(((((((((.(.(((((.((((...(((((.......((((((..((((...(((((((...(((((...)))))..((........))..)))))))..))))...)).))))(((((((......((.((........)).))))))))))))))...)))).)).)))).)))).....))))).......)))))....((((((.......(((((.............))))).....))))))..
Thermodynamic Ensemble Prediction
.......(((((..(((({{{{(((((,({(|||.{,|||{|||,.{(((...|||}...(((((.(((.....))).))))).......((((.(((((.(((((((((({,..,,....})))))).(((((...)))))((....))))))))..)))))))))..(((({(({{..,{||{,,||||(((,.....||||,,|||||||||(((,,,|||},|,,.{{{,,..((((((..(((((....(((...(((((({..((((((((,....,(((((.((,((((.((..,,,......}))))))))))))).})))))))..{||{{......{|....,.}}.,......)))}))))))))}}}.))))).))))))..,},,,,,,,},..(((((....))))).{{((((.{{{{|||,},,)|||})),|}||,,,,..||||||.|||||||||{{,{,.......,,,|{},{{{({........,}}}))}}},......,})||}|||,||||{{,..||,||||||,||||||{{|}}},},.||||,}}||||||{.{.{{(({...))))),.||,,..,...}}..}})))))}.})))}})))}|||.{((((|{....{{{{,,,...,{{{.,|{|||||,,,,})})))}.,))),,}.,})}}),},}},}))))}},))))..)))))....((((((.......(((({.............))))).....))))))..

Transcripts

ID Sequence Length GC content
NM_001363693.2 NCBI
CUUUCUUGGGCUCUAAGGACCCAGGAGUCUGGGUGCACAGCCUCCUUCU… 755 nt 0.5907
NM_005601.4 NCBI
CUUUCUUGGGCUCUAAGGACCCAGGAGUCUGGGUGCACAGCCUCCUUCU… 774 nt 0.5904
Summary

Involved in defense response to protozoan. Located in cytolytic granule membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Forensic Context

A study in humans demonstrated that the NKG7 was selected as a blood-specific candidate gene from a genome-wide microarray analysis of body fluids and was successfully validated by RT-PCR for forensic body fluid identification [Park et al. DOI:10.1016/j.fsigen.2012.09.001]. In a separate human study, the NKG7 was identified as a cytotoxic cell marker expressed in lymphoid cell clusters within a spatiotemporal single-cell atlas of skin wound healing [Liu et al. DOI:10.1016/j.stem.2024.11.013].