Basic Information

Symbol
NMRK2
RNA class
mRNA
Alias
Nicotinamide Riboside Kinase 2 MIBP NRK2 ITGB1BP3 Muscle-Specific Beta 1 Integrin Binding Protein Integrin Beta-1-Binding Protein 3 Nicotinic Acid Riboside Kinase 2 Ribosylnicotinic Acid Kinase 2 Ribosylnicotinamide Kinase 2 NmR-K 2 NRK 2 RNK 2 Integrin Beta 1 Binding Protein 3 Muscle Integrin-Binding Protein EC 2.7.1.173 EC 2.7.1.22
Location (GRCh38)
19:3932994-3943081
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Tissue/body fluid identification Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_170678.3
Sequence length
1160.0 nt
GC content
0.6284

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-485.80 kcal/mol
Thermodynamic ensemble
Free energy: -503.13 kcal/mol
Frequency: 0.0000
Diversity: 374.41
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
..((((..(((..(((((((............)))))))..)))..(((((....))))).......))))(((((((..(((((.((((.((((...(((.((((((..(((((((((((((((((.(((((.(((.(.....).))).))))...(((((.......))))).(((((....)))))((((((((..(((((...((........(((((.((((((......)))))).)).)))(((((((.(((....((((((((((((((.....))).)))...(((.....)))..((((((((((((..((.((((((...)))).)).))...))))))..........))))))..))))))))..........((((((..(((((((.(((((((((((.((.((((....)))).)).((((........)))).....)))))))))))..))..))))).....)))))).))).))))))).((((((((((((((((.((((((...))).))))))))((((....)))).((((....))))....((((((((((((((..(((((...((((....((....))....))))...))))).(((((...(((....)))...)))))......(((((((((.....((.((((((((((..(((.(..((((.....))))..)))).)).)))))))).))...)))).)))))))))))))...((((........))))..))).))))))))).))))).))...)))))....))))))))....).)))))))))((((.((.((((..(((((((.(((....)).)..))).))))..)))).)).)))).(((((.........)))))..))).))))).....)))))).)))))))..))))))..))).....)))))))((((((...(((((((............)))).))))))))).((((((((.(((.(((((.((.....(((((((((((((.......((.((((((.....))))))))....(((((((((........)))))...))))..)))))))))))))))))))))))....(((((.....))))))))))))).......
Thermodynamic Ensemble Prediction
..{{{(..(((..(((((((............)))))))..))}..(((((....))))).{,....})),(((((((,{((({{.((((.((((.,.(((.((((((,,(((((((({{{{{{{{(,((((((((((,...{((({{{{||}|{.,{{|,,.,{{{{,(((((((((((....)))))||||||{,{{({(((....,.......}|||||.((((((,.....)))))){||{||,(((((((.((((.{(({(((({,{,,,{|.,,.,))),})).}}|||,}}}})))}.((((((((((((..((.((((((...)))).)).))...))))))..........))))))..||,||,((((.....}}}},||,|}.((((({(.(((((((((((.((.((((....)))).)).((((........)))).....))))))))))).,,}..))))).....,|||||.,||,||||,||{(((((,({((({{{{{.((((((.,.|||.|}}||||}((({,,,{}}}}.{{{{..,,})))|,|,||||}}||||||||}||||||||,||||}.},||}}.,}}}}..|,{{{....))).(((((...(((....)))...))))),}}||.|||{{,||..||.,||,|||(((((||..{{|,|..(({(,,,,,|}||..|}||.||,}}||}}}}.}}..,},,},}))}})),,)))},,.{|||}},,,..,}|||.{||},}|||}}|||,|}}},.)),,,))),),,.})))}))))..,)).)))))})))((((.((.((((..(((((((,{((....)).}..)))}})))..)))).)).)))).{{{{{..,,,,,,,)))))..)))}}})))...,.)))))).)))))))..))))))..})).,.,.)))))))((((((,.,{((((((.......}}}}.}))},})})))))).{(((((((.(((.(((((.((.....{((((((((((((.......((.((((((.....)))))))).,..((({{{||{,{.,,,{,|}}}),,,))})}.)))))))))))))))))))))))....{((((.....))))))))))))}.......

Transcripts

ID Sequence Length GC content
NM_001289117.2 NCBI
CUUGUGAUUCACUGCUAAGGAUCUUAAGCCCACCUUGGCCCUGACCUCG… 1175 nt 0.6272
NM_001375467.2 NCBI
GGGACGCACUCCGGAGCGCACUGCGUGGUCGCACCCUACCCGGGCUGCC… 847 nt 0.6222
NM_001375468.2 NCBI
GGGACGCACUCCGGAGCGCACUGCGUGGUCGCACCCUACCCGGGCUGCC… 827 nt 0.6215
NM_001375469.2 NCBI
GGGACGCACUCCGGAGCGCACUGCGUGGUCGCACCCUACCCGGGCUGCC… 812 nt 0.6232
NM_170678.3 NCBI
CUUGUGAUUCACUGCUAAGGAUCUUAAGCCCACCUUGGCCCUGACCUCG… 1160 nt 0.6284
Summary

Enables ribosylnicotinamide kinase activity and ribosylnicotinate kinase activity. Predicted to be involved in NAD metabolic process. Predicted to act upstream of or within negative regulation of myoblast differentiation. Located in nucleoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Forensic Context

A study in humans developed a 17-plex mRNA assay for forensic organ tissue identification, where the NMRK2 was included as a general muscle marker for identifying both skeletal and heart muscle [Lindenbergh et al. DOI:10.1007/s00414-013-0895-7]. This assay demonstrated high specificity and sensitivity, successfully analyzing a blind test set of 20 specimens including mixtures and mock stabbing samples, with the NMRK2 contributing to the correct inference of muscle tissues. A study in humans demonstrated that the NMRK2 is a marker used in targeted massively parallel sequencing assays for heart muscle tissue identification [Haas et al. DOI:10.1016/j.fsigen.2021.102486]. This integrative review further notes that the NMRK2 is an mRNA marker for heart tissue identification, specifically for cause of death analysis [Lei et al. DOI:10.1093/gpbjnl/qzag007].