Basic Information
Symbol
NPC2
RNA class
mRNA
Alias
NPC Intracellular Cholesterol Transporter 2
HE1
EDDM1
Niemann-Pick Disease Type C2 Protein
Human Epididymis-Specific Protein 1
Epididymal Protein 1
NP-C2
Epididymis Secretory Sperm Binding Protein
Tissue-Specific Secretory Protein
Epididymal Secretory Protein E1
Niemann-Pick Disease, Type C2
He1
Location (GRCh38)
14:74476192-74494177
Forensic tag(s)
Tissue/body fluid identification
MANE select
Transcript ID
NM_006432.5
Sequence length
821.0 nt
GC content
0.4750
Secondary Structure
Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-231.70 kcal/mol
Thermodynamic ensemble
Free energy:
-249.25 kcal/mol
Frequency:
0.0000
Diversity:
244.87
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.........((((((....((((.....)))).(((((....(((((........)))))...))))).((((...)))).)))))).(((((...((((((....)))))))))))..((((((((((((....(((((.((((..(((((((((((.(((((..((.(((..((((.(..(((((((...............)))..))))..)))))........((......)).))).))..).))))...))))......))))).))...)))).)))))((((((...((((....))))....))))))...)))))...)))))))..((((((((((....((((((((((....(((((((((....((.(.......).)).....)))))))))(((((((((((((..((((((...((((....((((....(((((((....))))))).)))).)))).))))))..))))........(((((.(((((...((..(((.((((((....))))))))).)))))))...))))))))))))))....((((.(((((.((((.((((((.(((....))))))))).)))).)))).).)))).((((..((((((..((((....))))..))))))..))))....................))))))))))..................(((((..((((((((((........)))..)))))...))..)))))..((((((....)))))).............................)))))))))).....
Thermodynamic Ensemble Prediction
.......,.((,.((((,.((((.....)))).|,},}})}.{((((........)))))(((((.({.,(((...)))))))))),.(((((...((((((....))))))))))).,((((((((((((....(((((.(((({.(((((((((((.((((,..{{,(((..((((.{..{{(((({...............))}..,}}}..})}))........||,.....})})),.))..),))))...)))},....,})))).}}.,|}))).))))}((((((.,,((((....)))).,,.))))))...})))),,,)}))))}..{(((((((((..,,{(((((((({....(((((((((....{{.(.......,.},.....))))))))),{{(,(((,{(((..((((((...((((....((((....(((((((....))))))).)))}.)))).)))))}..))))))).|,,,({({{{(({{,..||{||({{,((((((...,||||}},}|,|{{(|||,..||||{,|||{({,,....{{((,{((((.((((.((((((.(((....))))))))).)))).)))),),}}))}})))}.{{{|||,,{{||,,..))))..)))))),}}}}}}....}}}},....{{{{{.|||||||}|,.{{,...,}}.},|}}}}||,,,}}}}|((((,((........)}))}),}}}}.,}}}))))},..|{{{{|....}))))|,,,,.....},,,,,,,........,}..)))))))))}..}}.
Transcripts
| ID | Sequence | Length | GC content |
|---|---|---|---|
| GGUCCGGGCGGGUCAGGCCUCUGAGGGGAUGGCAUGGGCGGAGACUGCA… | 1446 nt | 0.4993 | |
| CUUUCCCGAGCUUGGAACUUCGUUAUCCGCGAUGCGUUUCCUGGCAGCU… | 743 nt | 0.4778 | |
| CUUUCCCGAGCUUGGAACUUCGUUAUCCGCGAUGCGUUUCCUGGCAGCU… | 821 nt | 0.4750 |
Summary
This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy. [provided by RefSeq, Jul 2008]
Forensic Context
A review of forensic proteomics literature identifies the NPC2 as a protein marker found in seminal fluid for body fluid identification [Alex et al. DOI:10.1016/j.scijus.2025.101320].