Basic Information

Symbol
NPM1
RNA class
mRNA
Alias
Nucleophosmin 1 NPM Nucleophosmin B23 Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin) Nucleophosmin/Nucleoplasmin Family, Member 1 Nucleolar Phosphoprotein B23 Nucleolar Protein NO38 Numatrin Testicular Tissue Protein Li 128
Location (GRCh38)
5:171387086-171411810
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_002520.7
Sequence length
1320.0 nt
GC content
0.4129

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-335.40 kcal/mol
Thermodynamic ensemble
Free energy: -362.69 kcal/mol
Frequency: 0.0000
Diversity: 311.25
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
........((((.((..((((.((((...(((((((....)))))))((((((.....(((((((.((((((((.((((.(((((((.((((((..(((((.(((((..(((.(((..((((((((..(((......))).((((....((((((((((((..........)))))).))))))....(((((((..(((((..............((((((((..(((....((((.....))))))).))))))))....(((..(((((.(.((((....)))).))))))..))).........))))).)))))))....))))...........))))))))....))).)))))))).)))))(((((((((...((((((((...........)).))..))))..)))))))))...........)))).)))))))))))))(((((........)))))..(((.....))))))))))).))))).)).(((((....((((...(((.(((.....(((......)))(((((((((.....((........))....)))))))))(((((.(((((.((((........(((((((((..((((.....((.((.((((((((.((((((......((..(((........))).)).........((((.....))))..((((........((.((....))))........))))......)))))).)))))))).)).))..)))).(((((......)))))........((((......))))......((....))((((..(((((((.....((((........))))........)))))))..)))).)))))))))......(((((((..(((((.(((......))).))))))))))))....((((.(((.((((((.....)).)))))))))))((((.....))))....((((((..(((((........)))))..)))))))))))))))))))).......(((.......)))))).)))....))))....)))))))))))((((((((((((((((((.............(((((((((...(((((((((((......))))).......))))))...)))))))))((((((((((((..((((((.(((............)))..))))))..))))).)).)))))))))))))......))))))))))..(((((((....((........))...)))))))......)))).))))..))))))..
Thermodynamic Ensemble Prediction
........{(((.((..((((.((((...(((((((....)))))))||(((({{.,{((((((,.(((((,(,.(((,{(((((((.{,((((..(((((.(((((..(((.(((..((((((((,.(((......))).,,,,....{(((((((((((.,......,.)))))).)))))|{{{{(((....}}|||||,,,...........((((((((,.{(({...((((.....))))))))))))))))....(((..(((((.(.((((....)))).))))))..))}.,...,.,,|}}},.|||||||....,}}),.,))}}}...))))))))....))).)))))))).)))))(((((((((...(((({(((,.....,....))}.}..))))..)))))))))...........)))).),))))))))))),,|,|}}}}..},))}}))},,|,,,}||||||||||||.|}}}}.,}.,{{||...,|,.,,{{({,,.,|||,{{||{,,.,,,)).|||||{{{{.||..{(........}}..,,))))))))){((({({{(((.((((,{,.{{,,(((((((((.,{,{(,....((.((,((((({((,((((({,.,,..((..(((........))).)).||,.,|..||||.,..,||.,..((((........{(,{{....)}}}........)))).....}))}}}}.)))))))).)).)}..)))}.(((((......)))))........((((......))))......((....))((((..(((((((.....{,{{...{{,..,,))}.......)))))))..)))).)))))))}},,,...|||||||,.,,|||,|||......|||,||}}}||||||,..,.((((.((,{((((((.....)).))))))))))),{{||},,},)))}},.((((((..((({({({...}))))))..)))))))))))))))))))}{{{{{{((((({,....,})))))),,....,,...})))))||}))}}}{(((((((((((((((((,............(((((((((...(((((((((((......))))).......))))))...)))))))))((((((((((((..((((((.{((,,,.........)))..))))))..))))).)).))))))))))))}.....,)))))))))}..,{{{{((....{(,.......}}.,.)))))))......)))).))))..)))))},.

Transcripts

ID Sequence Length GC content
NM_001037738.3 NCBI
CUUUCCCUGGUGUGAUUCCGUCCUGCGCGGUUGUUCUCUGGAGCAGCGU… 1600 nt 0.3956
NM_001355006.2 NCBI
GGGCGAUGUCCUUGCUAAUUUGGAGACUGAUUCAGUCCCCUUUUGGCCC… 1355 nt 0.4081
NM_001355007.2 NCBI
CUUUCCCUGGUGUGAUUCCGUCCUGCGCGGUUGUUCUCUGGAGCAGCGU… 1240 nt 0.4161
NM_001355009.2 NCBI
CUUUCCCUGGUGUGAUUCCGUCCUGCGCGGUUGUUCUCUGGAGCAGCGU… 1513 nt 0.3979
NM_001355010.2 NCBI
CUUUCCCUGGUGUGAUUCCGUCCUGCGCGGUUGUUCUCUGGAGCAGCGU… 939 nt 0.4121
NM_002520.7 NCBI
CUUUCCCUGGUGUGAUUCCGUCCUGCGCGGUUGUUCUCUGGAGCAGCGU… 1320 nt 0.4129
NM_199185.4 NCBI
CUUUCCCUGGUGUGAUUCCGUCCUGCGCGGUUGUUCUCUGGAGCAGCGU… 1233 nt 0.4169
Summary

The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017] CIViC Summary for NPM1 Gene AML with mutated NPM1 is a provisional entity in the WHO classification of AML and is recommended to be tested in patients with cytogenetically normal AML (CN-AML). FLT3 mutations should be evaluated concurrently as they have prognostic consequences. NPM1 mutations are concentrated in exon 12, most frequently W288fs which results in cytoplasmic sequestration of the protein. Exon 12 NPM1 mutations in the absence of FLT3-ITD are associated with good prognostic outcomes. Mice expressing the Npm1-W288fs mutation develop myeloproliferative neoplasms but not overt leukemia, indicating it may require additional mutations to promote leukemic development.

Forensic Context

No relevant information is available at the moment.