Basic Information

Symbol
NPY
RNA class
mRNA
Alias
Neuropeptide Y PYY4 Prepro-Neuropeptide Y Pro-Neuropeptide Y
Location (GRCh38)
7:24284188-24291862
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
-
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000905.4
Sequence length
555.0 nt
GC content
0.5405

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-173.80 kcal/mol
Thermodynamic ensemble
Free energy: -181.60 kcal/mol
Frequency: 0.0000
Diversity: 87.09
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.........((.(((((((........)))).))).))..((..((((.((((((..........(((((.((((((((((((.(((((((.(....).))))..)))))))(((......))).((.(((.((((((((((.((((((((((((...(((((.((((......))))...)))))...))))))))......)))).))))).))))).))).)).........))))).))).............(((((((..((((.(((((.((((......))))...(((.....)))))))).).)))..))))))).((..(((..(((((((((..(((((.(((((....((...(((((.((((((((((((....((((.....)))).(((...............))).....(((.((((.....)))))))....))))))..)))...))))))))...))..))))).))))).)))))))))...)))..))...........)))))........)))))).))))..))....
Thermodynamic Ensemble Prediction
.........((.(((((((........)))).))).))..{{..((((.((((((,..,,...{|,,{||.((((((((((((.(((((((.(....).))))..))))))){{{.,,...}}}.((.(((.((((((((((.((((((((((((,,,(({{{.{{||,,,,,,)}}}...}||||...}}))))))..,,.,)))).))))).))))).))).)).........))))).))),,,,.,,,,....(((((((..((((.(((((.((((......))))...(((.....)))))))).).)))..))))))).{{.,(((.,(((((((((..(((((.(((((....((...(((({,((((((((((((....((((.....)))).(((...............))).....(((.((((.....)))))))....))))))..))),..})))))))...))..))))).))))).))))))))),,.}}}..,}..,,.....,})))))),......)))))).))))..}}....

Transcripts

ID Sequence Length GC content
NM_000905.4 NCBI
ACCCCAUCCGCUGGCUCUCACCCCUCGGAGACGCUCGCCCGACAGCAUA… 555 nt 0.5405
Summary

This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]

Forensic Context

No relevant information is available at the moment.