Basic Information

Symbol
NQO2
RNA class
mRNA
Alias
N-Ribosyldihydronicotinamide:Quinone Dehydrogenase 2 QR2 NRH:Quinone Oxidoreductase 2 Quinone Reductase 2 NMOR2 DHQV DIA6 Ribosyldihydronicotinamide Dehydrogenase [Quinone] N-Ribosyldihydronicotinamide:Quinone Reductase 2 NAD(P)H Quinone Dehydrogenase 2 NAD(P)H Menadione Oxidoreductase-1, Dioxin-Inducible-2 NAD(P)H Menadione Oxidoreductase 2, Dioxin-Inducible Ribosyldihydronicotinamide Dehydrogenase NAD(P)H Dehydrogenase, Quinone 2 NRH Dehydrogenase [Quinone] 2 EC 1.10.5.1
Location (GRCh38)
6:2987987-3022109
UCSC Genome Browser Search in Marker Scope
Forensic tag(s)
Cause of death analysis
External database
HGNC NCBI Ensembl OMIM UniProt GTEx

MANE select

Transcript ID
NM_000904.6
Sequence length
1073.0 nt
GC content
0.5508

Secondary Structure

Generated by RNAfold
Minimum free energy (MFE) structure:
Secondary structure that contributes a minimum of free energy.
Ensemble properties:
Thermodynamic properties of the Boltzmann ensemble.
Minimum free energy
-381.90 kcal/mol
Thermodynamic ensemble
Free energy: -402.93 kcal/mol
Frequency: 0.0000
Diversity: 340.11
MFE Structure Visualization
Structure Prediction
MFE Structure Prediction
.((((((((((.((((...(((((((((((..((.(((....(((((((((.......)))))))))....))).).)....)).)))).))).))...))))))))))))))(((((.(((((....((((.....(((((.((((((.......)))))).)))))))))))))))))))((((.((....(((((((.(((........))).))).)))).....))...))))..............(((((((......)))))))..((((((....((((((.((((((..((.(((.(((.(((((....(((...((((((..(((((.(.........(.(((...((.(((.(((((..(((((((((......((((((.((.((((.....(((((((....(((....(((((((((((...(((.((((...(((.((((......((((((((((((..........((((....)))))))))))....((((((..(((((((..(((.((((.(((..((((........))))((.(.(((((.((((((......((((....)))))))))).))))).).))..((((((.........)))))).))))))).))))))))))))))))((((((((((.(.(((.((...)).)))((((((((....))))))))...(((.((((((((....))))))))...))).).)))))...))))).)))))......)))))))...))))))).)))))))).))))))))))))).)))).))..))))))......)).))))))).))))).))).))..))).).......).))))).....))))))..)))..))))).((((((((((((((.((((((..((.....(((.((......)).)))........((((((((.(((...(((......))).))).)).)))))).....))..))))).).)).)).))))...))))))))).))).))...)))))).))...........))))..))))))..
Thermodynamic Ensemble Prediction
(({(({.{{(((((|({,,({,,(({,{{{,,,({((({{..{((((((((.......))))))))(((.....))).(((((((((.(((((((..,({({{((({...)))||||,.||{(({{.(((.(((({{(((((.((((((.,...,.)))))).))))}.})))))).))),))))..}...)))))).).)))))))))...}.)})))}}{{|{,..||,,|{||{{{,,.{{......,.(((((((......)))))))..((,{,({({{(((,,..,,|||}..|}}||{.,||.,,,,({{{.(({...{{{{{{..{||,|,}},},.,...}}|||,|,{{.(((.(((((..(((((((((......((((((.{{.{(,..{({.{((((((....{,{....(((((((((((....(((((((((((((.,.((((({..,((({.((((((({.,,...,,{|}|}}}})||.{{.((((........}))).}}|}|{{.((..((((...)))).)),,....})),}.))))))..,)}),)))))))))){{||...,||||..{{{{,.|||||.{((..((((((.......,.))))))....)})||||,|||||,((((((((((.((((..((.(((.((...)).)))))..)).)).)))))))}..,}},||.{{((((((....))))))))}}})))||,||,,,...,{{{(,{.{{{|||...,..})})))}).,.}}},)))))))).))),}})))))))})}}},)}..))))))......)))))}}))).))))).))),})},}}}})}}..{{{|{,,|||,,{..,,,,,,.,||||||||}||((||||||||(((({(({,,,.,,)).))))},.,,..,}}})),)))))}{{.,,({{,,|||}|{|}},|||},,,..}}|{||},||,||||}}.,}}}}}..}}}}},}.}},)).}}})}.,),)).,))....,...,.,}}}|||{|..{{........}},},.,)}}))..

Transcripts

ID Sequence Length GC content
NM_000904.6 NCBI
GCAGGUUCCGGGCUGCUUAGGUUGGCACCGGUCCGUGGUCCCCGGGGGC… 1073 nt 0.5508
NM_001290221.2 NCBI
GCAGGUUCCGGGCUGCUUAGGUUGGCACCGGUCCGUGGUCCCCGGGGGC… 1588 nt 0.5359
NM_001290222.2 NCBI
GCAGGUUCCGGGCUGCUUAGGUUGGCACCGGUCCGUGGUCCCCGGGGGC… 959 nt 0.5485
NM_001318940.2 NCBI
GCAGGUUCCGGGCUGCUUAGGUUGGCACCGGUCCGUGGUCCCCGGGGGC… 1355 nt 0.5638
Summary

This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Forensic Context

A study in humans using proteomics and RNA sequencing on peripheral blood samples from sepsis patients and healthy volunteers identified the NQO2 as a potential diagnostic biomarker for sepsis, where it was found to have a consistent mRNA and protein expression pattern and was lowly expressed in the sepsis group based on RNA sequencing data [Wang et al. DOI:10.2147/IDR.S380137].